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    Mme membrane metallo endopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 17380, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mmeprovided by MGI
    Official Full Name
    membrane metallo endopeptidaseprovided by MGI
    Primary source
    MGI:MGI:97004
    See related
    Ensembl:ENSMUSG00000027820 AllianceGenome:MGI:97004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEP; SFE; CD10; CALLA; 6030454K05Rik
    Summary
    Enables peptidase activity. Involved in amyloid-beta clearance; positive regulation of long-term synaptic potentiation; and sensory perception of pain. Acts upstream of or within amyloid-beta metabolic process. Located in several cellular components, including dendrite; neuron projection terminus; and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and mammary gland. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 8.6), kidney adult (RPKM 7.9) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Mme in Genome Data Viewer
    Location:
    3 E1; 3 29.97 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63202632..63291134)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63295211..63383713)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 4 (mitochondrial) pseudogene Neighboring gene STARR-seq mESC enhancer starr_07827 Neighboring gene STARR-seq mESC enhancer starr_07828 Neighboring gene STARR-seq mESC enhancer starr_07829 Neighboring gene predicted gene, 40064 Neighboring gene predicted gene, 57709 Neighboring gene STARR-seq mESC enhancer starr_07831 Neighboring gene STARR-seq mESC enhancer starr_07832 Neighboring gene predicted gene, 34240 Neighboring gene small transmembrane regulator of ion transport 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cardiolipin binding  
    enables cardiolipin binding  
    enables endopeptidase activity  
    enables exopeptidase activity  
    enables exopeptidase activity  
    enables metallocarboxypeptidase activity PubMed 
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metallopeptidase activity PubMed 
    enables metallopeptidase activity PubMed 
    enables oligopeptidase activity  
    enables oligopeptidase activity  
    enables peptidase activity PubMed 
    enables peptide binding  
    enables peptide binding  
    enables phosphatidylserine binding  
    enables phosphatidylserine binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance  
    involved_in amyloid-beta clearance PubMed 
    involved_in amyloid-beta clearance  
    involved_in amyloid-beta clearance by cellular catabolic process  
    involved_in amyloid-beta clearance by cellular catabolic process  
    acts_upstream_of_or_within amyloid-beta metabolic process PubMed 
    involved_in angiotensin maturation PubMed 
    involved_in angiotensin maturation PubMed 
    involved_in angiotensin maturation PubMed 
    involved_in bradykinin catabolic process  
    involved_in bradykinin catabolic process  
    involved_in cellular response to UV-A  
    involved_in cellular response to UV-A  
    involved_in cellular response to UV-B  
    involved_in cellular response to UV-B  
    involved_in cellular response to cytokine stimulus  
    involved_in cellular response to cytokine stimulus  
    involved_in creatinine metabolic process  
    involved_in creatinine metabolic process  
    involved_in hormone catabolic process  
    involved_in hormone catabolic process  
    involved_in kidney development  
    involved_in learning or memory  
    involved_in learning or memory  
    involved_in lung development  
    involved_in neuropeptide processing  
    involved_in neuropeptide processing  
    involved_in peptide metabolic process  
    involved_in peptide metabolic process  
    involved_in placenta development  
    involved_in positive regulation of long-term synaptic potentiation PubMed 
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of neurogenesis  
    involved_in protein catabolic process  
    involved_in protein catabolic process  
    involved_in protein processing  
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in replicative senescence  
    involved_in response to estrogen  
    involved_in response to estrogen  
    involved_in sensory perception of pain PubMed 
    involved_in substance P catabolic process  
    involved_in substance P catabolic process  
    Items 1 - 25 of 44
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in axon  
    located_in brush border  
    located_in brush border  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in dendrite PubMed 
    located_in early endosome  
    located_in early endosome  
    is_active_in extracellular region PubMed 
    located_in membrane PubMed 
    located_in membrane raft  
    located_in membrane raft  
    located_in neuron projection terminus PubMed 
    located_in neuronal cell body  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in presynapse  
    located_in synapse PubMed 
    located_in synaptic vesicle PubMed 
    located_in trans-Golgi network  
    located_in trans-Golgi network  
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    neprilysin
    Names
    atriopeptidase
    common acute lymphoblastic leukemia antigen
    enkephalinase
    neutral endopeptidase 24.11
    skin fibroblast elastase
    NP_001276391.1
    NP_001276392.1
    NP_001344264.1
    NP_032630.2
    XP_006501161.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289462.1NP_001276391.1  neprilysin

      See identical proteins and their annotated locations for NP_001276391.1

      Status: VALIDATED

      Source sequence(s)
      AC121840, AK031446, AK076908, BY145991
      Consensus CDS
      CCDS17381.1
      UniProtKB/Swiss-Prot
      Q61391, Q6NXX5, Q8K251
      Related
      ENSMUSP00000141544.2, ENSMUST00000194150.6
      Conserved Domains (1) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
    2. NM_001289463.1NP_001276392.1  neprilysin

      See identical proteins and their annotated locations for NP_001276392.1

      Status: VALIDATED

      Source sequence(s)
      AC121840, AC121993, AK031446, AK033824
      Consensus CDS
      CCDS17381.1
      UniProtKB/Swiss-Prot
      Q61391, Q6NXX5, Q8K251
      Related
      ENSMUSP00000029400.2, ENSMUST00000029400.7
      Conserved Domains (1) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
    3. NM_001357335.1NP_001344264.1  neprilysin

      Status: VALIDATED

      Source sequence(s)
      AC121840, AC121993
      Consensus CDS
      CCDS17381.1
      UniProtKB/Swiss-Prot
      Q61391, Q6NXX5, Q8K251
      Conserved Domains (1) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
    4. NM_008604.4NP_032630.2  neprilysin

      See identical proteins and their annotated locations for NP_032630.2

      Status: VALIDATED

      Source sequence(s)
      AC121840, AK031446
      Consensus CDS
      CCDS17381.1
      UniProtKB/Swiss-Prot
      Q61391, Q6NXX5, Q8K251
      Related
      ENSMUSP00000142205.2, ENSMUST00000194134.6
      Conserved Domains (1) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      63202632..63291134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501098.4XP_006501161.1  neprilysin isoform X1

      See identical proteins and their annotated locations for XP_006501161.1

      UniProtKB/Swiss-Prot
      Q61391, Q6NXX5, Q8K251
      Conserved Domains (1) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
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