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    Foxm1 forkhead box M1 [ Mus musculus (house mouse) ]

    Gene ID: 14235, updated on 17-Dec-2024

    Summary

    Official Symbol
    Foxm1provided by MGI
    Official Full Name
    forkhead box M1provided by MGI
    Primary source
    MGI:MGI:1347487
    See related
    Ensembl:ENSMUSG00000001517 AllianceGenome:MGI:1347487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WIN; Mpm2; Fkh16; Foxm1b; HFH-11B; MPHOSPH2
    Summary
    Enables transcription cis-regulatory region binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of DNA-templated transcription; and positive regulation of double-strand break repair. Acts upstream of or within several processes, including positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; and vasculogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study hepatocellular carcinoma; lung cancer; and type 2 diabetes mellitus. Orthologous to human FOXM1 (forkhead box M1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 46.4), limb E14.5 (RPKM 38.1) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Foxm1 in Genome Data Viewer
    Location:
    6 F3; 6 62.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128339957..128352849)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128362994..128375886)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TUB like protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E4867 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene STARR-positive B cell enhancer ABC_E8833 Neighboring gene testis expressed 52 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E4868 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4869 Neighboring gene FK506 binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  
    involved_in DNA repair  
    involved_in G2/M transition of mitotic cell cycle  
    involved_in G2/M transition of mitotic cell cycle  
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within liver development PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of stress-activated MAPK cascade  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of double-strand break repair PubMed 
    involved_in positive regulation of double-strand break repair  
    acts_upstream_of_or_within positive regulation of stem cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of Ras protein signal transduction  
    acts_upstream_of regulation of cell cycle  
    involved_in regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in regulation of reactive oxygen species metabolic process  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of_or_within vasculogenesis PubMed 
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    forkhead box protein M1
    Names
    forkhead homolog 16
    trident
    winged-helix transcription factor Trident

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008021.4NP_032047.4  forkhead box protein M1

      See identical proteins and their annotated locations for NP_032047.4

      Status: VALIDATED

      Source sequence(s)
      BC065067, BU702111
      Consensus CDS
      CCDS20570.1
      UniProtKB/TrEMBL
      Q6P1H7, Q8C7V5
      Related
      ENSMUSP00000073041.7, ENSMUST00000073316.13
      Conserved Domains (1) summary
      cd00059
      Location:234309
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      128339957..128352849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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