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    Cdadc1 cytidine and dCMP deaminase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 71891, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdadc1provided by MGI
    Official Full Name
    cytidine and dCMP deaminase domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919141
    See related
    Ensembl:ENSMUSG00000021982 AllianceGenome:MGI:1919141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NYD-SP15; 2310010M10Rik
    Summary
    Predicted to enable several functions, including deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Predicted to be involved in DNA cytosine deamination and cytidine deamination. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human CDADC1 (cytidine and dCMP deaminase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 3.1), frontal lobe adult (RPKM 2.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cdadc1 in Genome Data Viewer
    Location:
    14 C3; 14 31.48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59796837..59835433, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59559386..59597985, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45935 Neighboring gene SET domain, bifurcated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4112 Neighboring gene calcium binding protein 39-like Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36842 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene shisa family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytidine deaminase activity  
    enables cytidine deaminase activity  
    enables dCMP deaminase activity  
    enables importin-alpha family protein binding  
    enables protein homodimerization activity  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in DNA cytosine deamination  
    involved_in cytidine deamination  
    involved_in cytidine deamination  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    cytidine and dCMP deaminase domain-containing protein 1
    Names
    cytidine deaminase
    NP_001162007.1
    NP_001162008.1
    NP_001162009.1
    NP_001162010.1
    NP_082262.1
    XP_011243506.1
    XP_030103902.1
    XP_036014747.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168535.1NP_001162007.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001162007.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC147044, AK032600, AK038926, BE648840, CX242881
      Consensus CDS
      CCDS49514.1
      UniProtKB/TrEMBL
      G3UW39
      Related
      ENSMUSP00000153357.2, ENSMUST00000225839.2
      Conserved Domains (2) summary
      cd01286
      Location:320455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    2. NM_001168536.1NP_001162008.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001162008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK009280, AK039148, CX242881
      Consensus CDS
      CCDS49515.1
      UniProtKB/Swiss-Prot
      Q8BMD5
      Related
      ENSMUSP00000128064.2, ENSMUST00000171683.3
      Conserved Domains (2) summary
      cd01286
      Location:320455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    3. NM_001168537.1NP_001162009.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001162009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC147044, AK032600, AK038926, BE648840, CX242881
      Consensus CDS
      CCDS49513.1
      UniProtKB/Swiss-Prot
      Q8BMD5
      Related
      ENSMUSP00000022555.4, ENSMUST00000022555.11
      Conserved Domains (2) summary
      cd01286
      Location:320455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    4. NM_001168538.1NP_001162010.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC147044, AK032813, AK039148, CX242881
      Consensus CDS
      CCDS88678.1
      UniProtKB/Swiss-Prot
      Q8BMD5
      Related
      ENSMUSP00000128022.3, ENSMUST00000167100.9
      Conserved Domains (2) summary
      cd01286
      Location:320455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    5. NM_027986.3NP_082262.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_082262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK032813, CO039661, CX242881
      Consensus CDS
      CCDS36940.1
      UniProtKB/Swiss-Prot
      Q8BMD5, Q8BYL2, Q8BYN1, Q8C014, Q922P4, Q99KL2, Q9D7F3
      Related
      ENSMUSP00000052233.8, ENSMUST00000056997.15
      Conserved Domains (2) summary
      cd01286
      Location:320455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    RNA

    1. NR_153387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC147044, AK032813, AK039148, CX242881

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      59796837..59835433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245204.4XP_011243506.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd01286
      Location:320455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    2. XM_030248042.2XP_030103902.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl00269
      Location:20139
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    3. XM_036158854.1XP_036014747.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl00269
      Location:20139
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    RNA

    1. XR_004938452.1 RNA Sequence

    2. XR_004938455.1 RNA Sequence

    3. XR_004938454.1 RNA Sequence

    4. XR_004938451.1 RNA Sequence

    5. XR_004938450.1 RNA Sequence

    6. XR_004938448.1 RNA Sequence

    7. XR_004938449.1 RNA Sequence

    8. XR_004938456.1 RNA Sequence

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