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    Dagla diacylglycerol lipase, alpha [ Mus musculus (house mouse) ]

    Gene ID: 269060, updated on 9-Dec-2024

    Summary

    Official Symbol
    Daglaprovided by MGI
    Official Full Name
    diacylglycerol lipase, alphaprovided by MGI
    Primary source
    MGI:MGI:2677061
    See related
    Ensembl:ENSMUSG00000035735 AllianceGenome:MGI:2677061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nsddr
    Summary
    Enables monoacylglycerol lipase activity. Involved in arachidonate metabolic process; regulation of neuroinflammatory response; and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within cannabinoid biosynthetic process; monoacylglycerol biosynthetic process; and neuroblast proliferation. Located in dendritic spine membrane and varicosity. Is active in postsynaptic membrane. Is expressed in brain and olfactory epithelium. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 16.8), cerebellum adult (RPKM 13.6) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Dagla in Genome Data Viewer
    Location:
    19 A; 19 6.55 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10222629..10282323, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10245265..10304877, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11020 Neighboring gene transmembrane protein 258 Neighboring gene flap structure specific endonuclease 1 Neighboring gene myelin regulatory factor Neighboring gene STARR-seq mESC enhancer starr_45549 Neighboring gene predicted gene, 30042 Neighboring gene predicted gene, 30263 Neighboring gene synaptotagmin VII

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0659

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity PubMed 
    enables lipoprotein lipase activity  
    enables metal ion binding  
    enables monoacylglycerol lipase activity PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process  
    acts_upstream_of arachidonate metabolic process PubMed 
    involved_in arachidonate metabolic process PubMed 
    involved_in arachidonate metabolic process  
    acts_upstream_of_or_within cannabinoid biosynthetic process PubMed 
    involved_in diacylglycerol catabolic process  
    involved_in diacylglycerol catabolic process  
    involved_in diacylglycerol catabolic process  
    acts_upstream_of_or_within monoacylglycerol biosynthetic process PubMed 
    acts_upstream_of_or_within neuroblast proliferation PubMed 
    acts_upstream_of_or_within neurogenesis PubMed 
    involved_in regulation of neuroinflammatory response PubMed 
    involved_in retrograde trans-synaptic signaling by endocannabinoid  
    involved_in retrograde trans-synaptic signaling by endocannabinoid PubMed 
    involved_in retrograde trans-synaptic signaling by endocannabinoid PubMed 
    involved_in retrograde trans-synaptic signaling by endocannabinoid  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in dendrite membrane  
    located_in dendrite membrane  
    located_in dendritic spine membrane PubMed 
    located_in early endosome membrane  
    located_in early endosome membrane  
    located_in plasma membrane PubMed 
    located_in postsynaptic density membrane  
    located_in postsynaptic density membrane  
    is_active_in postsynaptic membrane  
    is_active_in postsynaptic membrane PubMed 
    located_in varicosity PubMed 

    General protein information

    Preferred Names
    diacylglycerol lipase-alpha
    Names
    DAGL-alpha
    DGL-alpha
    neural stem cell-derived dendrite regulator
    sn1-specific diacylglycerol lipase alpha
    NP_932782.2
    XP_017173702.1
    XP_036017498.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198114.2NP_932782.2  diacylglycerol lipase-alpha

      See identical proteins and their annotated locations for NP_932782.2

      Status: VALIDATED

      Source sequence(s)
      AK147384, BC112414, BP765314, CF539357, CJ127451
      Consensus CDS
      CCDS29574.1
      UniProtKB/Swiss-Prot
      A8WFL4, Q6WQJ1, Q6ZQ76
      UniProtKB/TrEMBL
      A4FU75
      Related
      ENSMUSP00000046358.5, ENSMUST00000039327.11
      Conserved Domains (1) summary
      cd00519
      Location:288529
      Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10222629..10282323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161605.1XP_036017498.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A8WFL4, Q6WQJ1, Q6ZQ76
      UniProtKB/TrEMBL
      A4FU75
      Conserved Domains (1) summary
      cd00519
      Location:288529
      Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
    2. XM_017318213.2XP_017173702.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A8WFL4, Q6WQJ1, Q6ZQ76
      UniProtKB/TrEMBL
      A4FU75
      Conserved Domains (1) summary
      cd00519
      Location:288529
      Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
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