Pla2g4b phospholipase A2, group IVB (cytosolic) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g4bprovided by MGI
Official Full Name: phospholipase A2, group IVB (cytosolic)provided by MGI
Primary source: MGI:MGI:2384819
See related: Ensembl:ENSMUSG00000098488 AllianceGenome:MGI:2384819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1013; cPLA2-beta; A030011C02Rik
Summary: Enables lysophospholipase activity and phospholipase A2 activity. Predicted to be involved in glycerophospholipid catabolic process. Predicted to be located in early endosome membrane and mitochondrial inner membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to several human genes including PLA2G4B (phospholipase A2 group IVB). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 10.6), CNS E14 (RPKM 10.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.09 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119863914..119873514)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (120033433..120043033)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation.
Title: Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation.
TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses
Title: Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.
murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta
Title: Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pla2g4b (e-PCR), detects polymorphism
- UniSTS:546948

Readthrough Gm28042

Readthrough gene: Gm28042, Included gene: Jmjd7

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytosolic phospholipase A2 beta

Names: lysophospholipase A1 group IVB; phospholipase A2 group IVB

NP_663353.3

EC 3.1.1.4

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145378.4 → NP_663353.3 cytosolic phospholipase A2 beta

See identical proteins and their annotated locations for NP_663353.3

Status: VALIDATED

Source sequence(s)

AK137721, AL833774, DQ888308

Consensus CDS

CCDS38209.2

UniProtKB/Swiss-Prot

P0C871

UniProtKB/TrEMBL

B7ZCM8, Q06G06

Related

ENSMUSP00000118458.2, ENSMUST00000126150.2

Conserved Domains (2) summary

cd04036
Location:19 → 137

C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

cl11396
Location:250 → 779

Patatin_and_cPLA2; Patatins and Phospholipases