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    Maco1 macoilin 1 [ Mus musculus (house mouse) ]

    Gene ID: 66146, updated on 9-Dec-2024

    Summary

    Official Symbol
    Maco1provided by MGI
    Official Full Name
    macoilin 1provided by MGI
    Primary source
    MGI:MGI:1913396
    See related
    Ensembl:ENSMUSG00000028826 AllianceGenome:MGI:1913396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C61; Tmem57; 1110007C24Rik; 9230118A01Rik
    Summary
    Predicted to enable microtubule binding activity. Involved in brain development. Located in several cellular components, including axon; neuron projection terminus; and nuclear membrane. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and testis. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.9), CNS E18 (RPKM 14.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Maco1 in Genome Data Viewer
    Location:
    4 D3; 4 67.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134530070..134581242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134802759..134853931, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 1C, member 1 Neighboring gene predicted gene, 42326 Neighboring gene STARR-seq mESC enhancer starr_11682 Neighboring gene STARR-seq mESC enhancer starr_11683 Neighboring gene STARR-positive B cell enhancer ABC_E9086 Neighboring gene STARR-positive B cell enhancer ABC_E10265 Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3527 Neighboring gene STARR-seq mESC enhancer starr_11687 Neighboring gene STARR-seq mESC enhancer starr_11688 Neighboring gene STARR-positive B cell enhancer ABC_E2718 Neighboring gene STARR-positive B cell enhancer ABC_E4682 Neighboring gene STARR-seq mESC enhancer starr_11693 Neighboring gene Rh blood group, D antigen Neighboring gene transmembrane protein 50A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding  
    Process Evidence Code Pubs
    involved_in brain development PubMed 
    involved_in chemotaxis  
    involved_in neuronal signal transduction  
    involved_in neuronal signal transduction  
    involved_in neuronal signal transduction  
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in neuron projection PubMed 
    located_in neuron projection terminus PubMed 
    is_active_in nuclear membrane  
    located_in nuclear membrane PubMed 
    located_in nucleus PubMed 
    is_active_in rough endoplasmic reticulum membrane  
    located_in rough endoplasmic reticulum membrane  
    located_in rough endoplasmic reticulum membrane  
    located_in synapse PubMed 

    General protein information

    Preferred Names
    macoilin
    Names
    brain-specific adapter protein C61
    brain-specific adaptor protein C61
    transmembrane protein 57

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355499.1NP_001342428.1  macoilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK038972, AY846873
      UniProtKB/TrEMBL
      Q80YA4
      Conserved Domains (1) summary
      pfam09726
      Location:19606
      Macoilin; Transmembrane protein
    2. NM_001355500.1NP_001342429.1  macoilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AY846873
      UniProtKB/TrEMBL
      Q80YA4
      Conserved Domains (1) summary
      pfam09726
      Location:1485
      Macoilin; Transmembrane protein
    3. NM_001355501.1NP_001342430.1  macoilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AY846873
      UniProtKB/TrEMBL
      Q80YA4
      Conserved Domains (1) summary
      pfam09726
      Location:1485
      Macoilin; Transmembrane protein
    4. NM_025382.6NP_079658.2  macoilin isoform 1

      See identical proteins and their annotated locations for NP_079658.2

      Status: VALIDATED

      Source sequence(s)
      AY846873
      Consensus CDS
      CCDS18777.1
      UniProtKB/Swiss-Prot
      Q7TQE6
      UniProtKB/TrEMBL
      Q80YA4
      Related
      ENSMUSP00000030628.8, ENSMUST00000030628.15
      Conserved Domains (3) summary
      TIGR03462
      Location:29113
      CarR_dom_SF; lycopene cyclase domain
      pfam09726
      Location:2662
      Macoilin; Transmembrane protein
      pfam16331
      Location:386462
      TolA_bind_tri; TolA binding protein trimerization

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134530070..134581242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164305.1XP_036020198.1  macoilin isoform X2

      Conserved Domains (1) summary
      pfam09726
      Location:1238
      Macoilin; Macoilin family
    2. XM_006539100.4XP_006539163.1  macoilin isoform X1

      Conserved Domains (1) summary
      pfam09726
      Location:2384
      Macoilin; Macoilin family

    RNA

    1. XR_004941943.1 RNA Sequence

    2. XR_001784176.2 RNA Sequence

    3. XR_004941944.1 RNA Sequence

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