Ripor1 RHO family interacting cell polarization regulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ripor1provided by MGI
Official Full Name: RHO family interacting cell polarization regulator 1provided by MGI
Primary source: MGI:MGI:1922937
See related: Ensembl:ENSMUSG00000038604 AllianceGenome:MGI:1922937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam65a; 2310066E14Rik
Summary: Predicted to enable 14-3-3 protein binding activity. Predicted to be involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Located in cytoplasm. Is expressed in several structures, including adrenal gland; genitourinary system; hemolymphoid system; liver; and lung. Orthologous to human RIPOR1 (RHO family interacting cell polarization regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 26.2), lung adult (RPKM 19.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106320588..106348851)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105594087..105622219)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of Golgi localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Rho guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rho family-interacting cell polarization regulator 1

Names: family with sequence similarity 65, member A; protein FAM65A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081241.2 → NP_001074710.2 rho family-interacting cell polarization regulator 1

See identical proteins and their annotated locations for NP_001074710.2

Status: VALIDATED

Source sequence(s)

AK122573, BB852730, BC079880

Consensus CDS

CCDS52660.1

UniProtKB/Swiss-Prot

G5E8A2, Q68FE6, Q80T73, Q8K0T1, Q9D6R4

Related

ENSMUSP00000039966.9, ENSMUST00000043531.10

Conserved Domains (4) summary

pfam05109
Location:444 → 749

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:1097 → 1127

HEAT; HEAT repeat [structural motif]

pfam13646
Location:1125 → 1189

HEAT_2; HEAT repeats

pfam15903
Location:17 → 365

PL48; Filopodia upregulated, FAM65

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

106320588..106348851

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248531.4 → XP_011246833.2 rho family-interacting cell polarization regulator 1 isoform X1

Conserved Domains (4) summary

pfam05109
Location:524 → 829

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:1177 → 1207

HEAT; HEAT repeat [structural motif]

pfam13646
Location:1205 → 1269

HEAT_2; HEAT repeats

pfam15903
Location:97 → 445

PL48; Filopodia upregulated, FAM65
XM_011248532.4 → XP_011246834.2 rho family-interacting cell polarization regulator 1 isoform X2

Conserved Domains (4) summary

pfam05109
Location:524 → 829

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:1176 → 1206

HEAT; HEAT repeat [structural motif]

pfam13646
Location:1204 → 1268

HEAT_2; HEAT repeats

pfam15903
Location:97 → 445

PL48; Filopodia upregulated, FAM65
XM_036154352.1 → XP_036010245.1 rho family-interacting cell polarization regulator 1 isoform X6

Conserved Domains (2) summary

pfam05109
Location:561 → 829

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam15903
Location:97 → 445

PL48; Filopodia upregulated, FAM65
XM_036154351.1 → XP_036010244.1 rho family-interacting cell polarization regulator 1 isoform X4

UniProtKB/Swiss-Prot

G5E8A2, Q68FE6, Q80T73, Q8K0T1, Q9D6R4

Conserved Domains (4) summary

pfam05109
Location:444 → 749

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:1097 → 1127

HEAT; HEAT repeat [structural motif]

pfam13646
Location:1125 → 1189

HEAT_2; HEAT repeats

pfam15903
Location:17 → 365

PL48; Filopodia upregulated, FAM65
XM_006531461.5 → XP_006531524.1 rho family-interacting cell polarization regulator 1 isoform X3

Conserved Domains (4) summary

pfam05109
Location:495 → 763

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:1111 → 1141

HEAT; HEAT repeat [structural motif]

pfam15903
Location:31 → 379

PL48; Filopodia upregulated, FAM65

pfam13646
Location:1139 → 1203

HEAT_2; HEAT repeats
XM_006531463.2 → XP_006531526.1 rho family-interacting cell polarization regulator 1 isoform X5

Conserved Domains (4) summary

pfam05109
Location:447 → 715

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:1063 → 1093

HEAT; HEAT repeat [structural motif]

pfam15903
Location:2 → 331

PL48; Filopodia upregulated, FAM65

pfam13646
Location:1091 → 1155

HEAT_2; HEAT repeats
XM_030243830.1 → XP_030099690.1 rho family-interacting cell polarization regulator 1 isoform X7

Conserved Domains (4) summary

pfam05109
Location:286 → 591

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:939 → 969

HEAT; HEAT repeat [structural motif]

pfam15903
Location:1 → 207

PL48; Filopodia upregulated, FAM65

pfam13646
Location:967 → 1031

HEAT_2; HEAT repeats