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    Naip7 NLR family, apoptosis inhibitory protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 53880, updated on 9-Dec-2024

    Summary

    Official Symbol
    Naip7provided by MGI
    Official Full Name
    NLR family, apoptosis inhibitory protein 7provided by MGI
    Primary source
    MGI:MGI:1858256
    See related
    AllianceGenome:MGI:1858256
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Birc1g; Naip-rs4B
    Summary
    This gene is found in 129X1 mice, but not in C57BL/6J mice, so it is not present in GRCm38.p4 (see PMID:12483212). [provided by RefSeq, Mar 2019]
    Annotation information
    not in current annotation release
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    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyroptotic inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_negative_effect regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of IPAF inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 1g
    Names
    neuronal apoptosis inhibitory protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021545.1NP_067520.1  baculoviral IAP repeat-containing protein 1g

      See identical proteins and their annotated locations for NP_067520.1

      Status: PROVISIONAL

      Source sequence(s)
      AH009619
      UniProtKB/Swiss-Prot
      Q9JIB3
      UniProtKB/TrEMBL
      Q8CH64
      Conserved Domains (6) summary
      cd09293
      Location:10721271
      AMN1; Antagonist of mitotic exit network protein 1
      smart00238
      Location:159229
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:279346
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00033
      Location:10551078
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:11321156
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:464618
      NACHT; NACHT domain