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    Glmn glomulin, FKBP associated protein [ Mus musculus (house mouse) ]

    Gene ID: 170823, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glmnprovided by MGI
    Official Full Name
    glomulin, FKBP associated proteinprovided by MGI
    Primary source
    MGI:MGI:2141180
    See related
    Ensembl:ENSMUSG00000029276 AllianceGenome:MGI:2141180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fap48; Fap68; 9330160J16Rik
    Summary
    Predicted to enable hepatocyte growth factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase inhibitor activity. Acts upstream of or within circulatory system development and neural tube closure. Predicted to be part of Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; and Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including arterial system; respiratory system; skeleton; skin; and urinary system. Human ortholog(s) of this gene implicated in arteriovenous malformation; glomangioma; and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.4), CNS E18 (RPKM 3.9) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Glmn in Genome Data Viewer
    Location:
    5 F; 5 52.23 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107696828..107745754, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107548962..107597888, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 8 Neighboring gene predicted gene, 33885 Neighboring gene LSM12 homolog pseudogene Neighboring gene RIKEN cDNA 1700028K03 gene Neighboring gene STARR-seq mESC enhancer starr_13890 Neighboring gene STARR-positive B cell enhancer ABC_E1683 Neighboring gene RNA polymerase II associated protein 2 Neighboring gene RIKEN cDNA A930041C12 gene Neighboring gene Gfi1 +35 kb enhancer Neighboring gene RIKEN cDNA 4930428O21 gene Neighboring gene +19.5 kb enhancer downstream of Gfi1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Clone Names

    • MGC6885

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hepatocyte growth factor receptor binding  
    enables hepatocyte growth factor receptor binding  
    enables protein binding PubMed 
    enables signaling receptor binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-protein transferase inhibitor activity  
    enables ubiquitin-protein transferase inhibitor activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor signaling pathway  
    acts_upstream_of_or_within circulatory system development PubMed 
    involved_in epigenetic regulation of gene expression  
    involved_in epigenetic regulation of gene expression  
    involved_in muscle cell differentiation  
    involved_in muscle cell differentiation  
    involved_in negative regulation of T cell proliferation  
    involved_in negative regulation of T cell proliferation  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    acts_upstream_of_or_within neural tube closure PubMed 
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of cytokine production  
    acts_upstream_of_or_within positive regulation of interleukin-2 production  
    involved_in positive regulation of interleukin-2 production  
    involved_in positive regulation of interleukin-2 production  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of phosphorylation  
    acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in vasculogenesis  
    involved_in vasculogenesis  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex  
    part_of Cul3-RING ubiquitin ligase complex  
    part_of Cul4A-RING E3 ubiquitin ligase complex  
    part_of cullin-RING ubiquitin ligase complex  
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    glomulin
    Names
    FAP
    FK506-binding protein-associated protein
    FKBP-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161738.1NP_001155210.1  glomulin isoform a

      See identical proteins and their annotated locations for NP_001155210.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC134411, AK034160
      Consensus CDS
      CCDS19505.1
      UniProtKB/Swiss-Prot
      Q3TFR5, Q8BZM1, Q99LB8
      UniProtKB/TrEMBL
      Q3TMW7
      Related
      ENSMUSP00000080766.3, ENSMUST00000082121.9
      Conserved Domains (1) summary
      pfam08568
      Location:1527
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
    2. NM_001161739.1NP_001155211.1  glomulin isoform b

      See identical proteins and their annotated locations for NP_001155211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AC117574, AC134411, AK169045
      Consensus CDS
      CCDS51587.1
      UniProtKB/TrEMBL
      Q3T9A5, Q3TMW7
      Related
      ENSMUSP00000098509.4, ENSMUST00000100949.10
      Conserved Domains (1) summary
      pfam08568
      Location:1462
      Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin
    3. NM_133248.2NP_573511.2  glomulin isoform a

      See identical proteins and their annotated locations for NP_573511.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC134411, AK169045, BY013339
      Consensus CDS
      CCDS19505.1
      UniProtKB/Swiss-Prot
      Q3TFR5, Q8BZM1, Q99LB8
      UniProtKB/TrEMBL
      Q3TMW7
      Related
      ENSMUSP00000077168.7, ENSMUST00000078021.13
      Conserved Domains (1) summary
      pfam08568
      Location:1527
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107696828..107745754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249410.3XP_011247712.1  glomulin isoform X2

      Conserved Domains (1) summary
      pfam08568
      Location:14224
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
    2. XM_030254179.1XP_030110039.1  glomulin isoform X2

      Conserved Domains (1) summary
      pfam08568
      Location:14224
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
    3. XM_006534800.5XP_006534863.1  glomulin isoform X1

      See identical proteins and their annotated locations for XP_006534863.1

      UniProtKB/Swiss-Prot
      Q3TFR5, Q8BZM1, Q99LB8
      UniProtKB/TrEMBL
      Q3TMW7
      Conserved Domains (1) summary
      pfam08568
      Location:1527
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
    4. XM_017320694.3XP_017176183.1  glomulin isoform X2

      Conserved Domains (1) summary
      pfam08568
      Location:14224
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    RNA

    1. XR_001784631.2 RNA Sequence

      Related
      ENSMUST00000124546.8
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