U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ttll2 tubulin tyrosine ligase-like family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 100216474, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ttll2provided by MGI
    Official Full Name
    tubulin tyrosine ligase-like family, member 2provided by MGI
    Primary source
    MGI:MGI:3644030
    See related
    Ensembl:ENSMUSG00000079722 AllianceGenome:MGI:3644030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG625850
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in ciliary basal body. Orthologous to human TTLL2 (tubulin tyrosine ligase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: After Build 37.1 (Aug 2008), MGI and NCBI noted that the annotation of Ttll2 was incorrect. Mouse chromosome 17 has three segmental duplications and Ttll2 exists in the most proximal duplication. At that time the name of GeneID 625850 was changed to ENSMUSG00000079713 and a new GeneID (100216474) was created for Ttll2. [13 Feb 2013]
    Expression
    Biased expression in testis adult (RPKM 6.7), large intestine adult (RPKM 1.6) and 2 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ttll2 in Genome Data Viewer
    Location:
    17 A1; 17 4.72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7618026..7631434, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (7350627..7364035, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 31, D17Leh66a region Neighboring gene t-complex protein 10a Neighboring gene unc-93 homolog A2 Neighboring gene predicted gene, 26057 Neighboring gene STARR-seq mESC enhancer starr_41752 Neighboring gene predicted gene, 36458

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    2. Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage. Ho KH, et al. Dev Cell, 2023 Dec 4. PMID 37890489
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    probable tubulin polyglutamylase TTLL2
    Names
    putative polyglutamylase
    tubulin--tyrosine ligase-like protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098267.2 → NP_001091737.1  probable tubulin polyglutamylase TTLL2

      See identical proteins and their annotated locations for NP_001091737.1

      Status: VALIDATED

      Source sequence(s)
      AC117241
      Consensus CDS
      CCDS49941.1
      UniProtKB/Swiss-Prot
      A4Q9E4
      Conserved Domains (1) summary
      pfam03133
      Location:97 → 370
      TTL; Tubulin-tyrosine ligase family

    2. NM_001414354.1 → NP_001401283.1  probable tubulin polyglutamylase TTLL2

      Status: VALIDATED

      Source sequence(s)
      AC117241
      UniProtKB/Swiss-Prot
      A4Q9E4
      Related
      ENSMUSP00000111413.2, ENSMUST00000115747.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      7618026..7631434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246174.3 → XP_011244476.1  probable tubulin polyglutamylase TTLL2 isoform X2

      See identical proteins and their annotated locations for XP_011244476.1

      UniProtKB/Swiss-Prot
      A4Q9E4
      Conserved Domains (1) summary
      pfam03133
      Location:97 → 370
      TTL; Tubulin-tyrosine ligase family

    2. XM_011246171.3 → XP_011244473.1  probable tubulin polyglutamylase TTLL2 isoform X1

      Conserved Domains (1) summary
      pfam03133
      Location:108 → 381
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4Q9E4.1 GenPept UniProtKB/Swiss-Prot:A4Q9E4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous