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    Tcaim T cell activation inhibitor, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcaimprovided by RGD
    Official Full Name
    T cell activation inhibitor, mitochondrialprovided by RGD
    Primary source
    RGD:1560717
    See related
    EnsemblRapid:ENSRNOG00000004085 AllianceGenome:RGD:1560717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Toag1; TOAG-1; RGD1560717
    Summary
    Predicted to be active in mitochondrion. Orthologous to human TCAIM (T cell activation inhibitor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 371.6), Muscle (RPKM 170.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tcaim in Genome Data Viewer
    Location:
    8q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (131292275..131323557)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (122414827..122446105)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (131845673..131876896)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690480 Neighboring gene uncharacterized LOC102550701 Neighboring gene microRNA 138-1 Neighboring gene testis and ovary specific TOPAZ 1 Neighboring gene similar to human chromosome 3 open reading frame 86 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger protein 445

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies. Keeren K, et al. J Immunol, 2009 Sep 15. PMID 19684086
    2. Identification of gene markers for the prediction of allograft rejection or permanent acceptance. Sawitzki B, et al. Am J Transplant, 2007 May. PMID 17456197
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-cell activation inhibitor, mitochondrial
    Names
    Tolerance-associated gene-1
    tolerance-associated gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110838.2 → NP_001104308.2  T-cell activation inhibitor, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      A6I484, P0DKR2
      Related
      ENSRNOP00000099894.1, ENSRNOT00000171499.1

    2. NM_001433878.1 → NP_001420807.1  T-cell activation inhibitor, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2Q1X7

    3. NM_001433879.1 → NP_001420808.1  T-cell activation inhibitor, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2Q1X7

    4. NM_001433880.1 → NP_001420809.1  T-cell activation inhibitor, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2Q1X7

    5. NM_001433881.1 → NP_001420810.1  T-cell activation inhibitor, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2Q1X7

    6. NM_001433882.1 → NP_001420811.1  T-cell activation inhibitor, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2Q1X7

    7. NM_001433883.1 → NP_001420812.1  T-cell activation inhibitor, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2Q1X7

    8. NM_001433884.1 → NP_001420813.1  T-cell activation inhibitor, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AN19, A0A8L2Q1X7

    9. NM_001433885.1 → NP_001420814.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    10. NM_001433886.1 → NP_001420815.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    11. NM_001433887.1 → NP_001420816.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    12. NM_001433888.1 → NP_001420817.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    13. NM_001433889.1 → NP_001420818.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    14. NM_001433890.1 → NP_001420819.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    15. NM_001433891.1 → NP_001420820.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    16. NM_001433892.1 → NP_001420821.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    17. NM_001433893.1 → NP_001420822.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    18. NM_001433894.1 → NP_001420823.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    19. NM_001433895.1 → NP_001420824.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    20. NM_001433896.1 → NP_001420825.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      131292275..131323557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766723.4 → XP_008764945.1  T-cell activation inhibitor, mitochondrial isoform X3

      Conserved Domains (2) summary
      pfam14687
      Location:9 → 95
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:156 → 456
      DUF4461; Domain of unknown function (DUF4461)

    2. XM_063265855.1 → XP_063121925.1  T-cell activation inhibitor, mitochondrial isoform X5

    3. XM_008766719.4 → XP_008764941.1  T-cell activation inhibitor, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_008764941.1

      UniProtKB/TrEMBL
      A0A8I6AN19, A0A8L2Q1X7
      Conserved Domains (2) summary
      pfam14687
      Location:9 → 95
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:156 → 456
      DUF4461; Domain of unknown function (DUF4461)

    4. XM_063265856.1 → XP_063121926.1  T-cell activation inhibitor, mitochondrial isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q1X7

    5. XM_008766718.4 → XP_008764940.1  T-cell activation inhibitor, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q1X7
      Related
      ENSRNOP00000094919.2, ENSRNOT00000117252.2
      Conserved Domains (2) summary
      pfam14687
      Location:29 → 115
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:176 → 476
      DUF4461; Domain of unknown function (DUF4461)

    6. XM_039081818.2 → XP_038937746.1  T-cell activation inhibitor, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q1X7
      Conserved Domains (2) summary
      pfam14687
      Location:8 → 81
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:143 → 443
      DUF4461; Domain of unknown function (DUF4461)

    7. XM_008766720.2 → XP_008764942.1  T-cell activation inhibitor, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_008764942.1

      UniProtKB/TrEMBL
      A0A8I6AN19, A0A8L2Q1X7
      Conserved Domains (2) summary
      pfam14687
      Location:9 → 95
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:156 → 456
      DUF4461; Domain of unknown function (DUF4461)

    8. XM_039081817.2 → XP_038937745.1  T-cell activation inhibitor, mitochondrial isoform X1

      Conserved Domains (2) summary
      pfam14687
      Location:33 → 138
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:200 → 500
      DUF4461; Domain of unknown function (DUF4461)

    9. XM_006244194.4 → XP_006244256.1  T-cell activation inhibitor, mitochondrial isoform X1

      Conserved Domains (2) summary
      pfam14687
      Location:33 → 138
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:200 → 500
      DUF4461; Domain of unknown function (DUF4461)

    10. XM_008766721.3 → XP_008764943.1  T-cell activation inhibitor, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_008764943.1

      UniProtKB/TrEMBL
      A0A8I6AN19, A0A8L2Q1X7
      Conserved Domains (2) summary
      pfam14687
      Location:9 → 95
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:156 → 456
      DUF4461; Domain of unknown function (DUF4461)

    11. XM_017595773.3 → XP_017451262.1  T-cell activation inhibitor, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8I6AN19, A0A8L2Q1X7
      Conserved Domains (2) summary
      pfam14687
      Location:9 → 95
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:156 → 456
      DUF4461; Domain of unknown function (DUF4461)

    12. XM_063265854.1 → XP_063121924.1  T-cell activation inhibitor, mitochondrial isoform X1

      Related
      ENSRNOP00000005440.6, ENSRNOT00000005440.8

    13. XM_039081821.2 → XP_038937749.1  T-cell activation inhibitor, mitochondrial isoform X5

      Conserved Domains (1) summary
      pfam14688
      Location:34 → 334
      DUF4461; Domain of unknown function (DUF4461)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DKR2.1 GenPept UniProtKB/Swiss-Prot:P0DKR2

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