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    Rab3c RAB3C, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab3cprovided by RGD
    Official Full Name
    RAB3C, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:620923
    See related
    EnsemblRapid:ENSRNOG00000011623 AllianceGenome:RGD:620923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP-dependent protein binding activity; GTPase activity; and myosin V binding activity. Predicted to be involved in antigen processing and presentation and exocytosis. Predicted to act upstream of or within regulation of exocytosis. Is active in synaptic vesicle membrane. Orthologous to human RAB3C (RAB3C, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 220.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab3c in Genome Data Viewer
    Location:
    2q14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (43353822..43577226, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (41627720..41843541, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (41570955..41786681, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D Neighboring gene uncharacterized LOC120101084 Neighboring gene uncharacterized LOC108349943 Neighboring gene Grb2-binding adaptor protein, transmembrane Neighboring gene polo-like kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis. Fischer von Mollard G, et al. J Biol Chem, 1994 Apr 15. PMID 8157621
    2. Differential expression of rab3 isoforms in oligodendrocytes and astrocytes. Madison DL, et al. J Neurosci Res, 1996 Aug 1. PMID 8841986
    3. Cloning and tissue expression of the rat RAB 3C GTP-binding protein. Viggeswarapu M, et al. Biochem Biophys Res Commun, 1996 Oct 23. PMID 8885988
    4. Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins. Wada M, et al. J Biol Chem, 1997 Feb 14. PMID 9020086
    5. Insulin and okadaic acid induce Rab4 redistribution in adipocytes. Cormont M, et al. J Biol Chem, 1993 Sep 15. PMID 8366094

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-3C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433831.1 → NP_001420760.1  ras-related protein Rab-3C isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8L2Q7P7, A0A8L2R781, A6I5M1

    2. NM_133536.3 → NP_598220.2  ras-related protein Rab-3C isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P62824
      UniProtKB/TrEMBL
      A0A8L2R781, A6I5M2
      Related
      ENSRNOP00000096986.1, ENSRNOT00000116600.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      43353822..43577226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760719.4 → XP_008758941.1  ras-related protein Rab-3C isoform X2

      Related
      ENSRNOP00000015871.4, ENSRNOT00000015871.8
      Conserved Domains (1) summary
      cd01865
      Location:28 → 192
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    2. XM_039101613.2 → XP_038957541.1  ras-related protein Rab-3C isoform X1

      UniProtKB/Swiss-Prot
      P62824
      UniProtKB/TrEMBL
      A0A8L2R781, A6I5M2
      Related
      ENSRNOP00000104946.1, ENSRNOT00000170596.1
      Conserved Domains (1) summary
      cd01865
      Location:30 → 194
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    3. XM_063281218.1 → XP_063137288.1  ras-related protein Rab-3C isoform X3

      UniProtKB/TrEMBL
      A0A8L2R781
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62824.1 GenPept UniProtKB/Swiss-Prot:P62824

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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