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    Hepacam2 HEPACAM family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hepacam2provided by RGD
    Official Full Name
    HEPACAM family member 2provided by RGD
    Primary source
    RGD:1305697
    See related
    EnsemblRapid:ENSRNOG00000009711 AllianceGenome:RGD:1305697
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305697
    Summary
    Predicted to be involved in centrosome cycle. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be active in Golgi apparatus; microtubule cytoskeleton; and midbody. Orthologous to human HEPACAM2 (HEPACAM family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 53.6), Spleen (RPKM 20.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hepacam2 in Genome Data Viewer
    Location:
    4q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (32400523..32435936, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (31446195..31480859, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (28402862..28437722, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 9 like 2 Neighboring gene sterile alpha motif domain containing 9 like Neighboring gene VPS50 subunit of EARP/GARPII complex Neighboring gene calcitonin receptor Neighboring gene microRNA 653

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation. Ozaki Y, et al. Mol Cell, 2012 Sep 14. PMID 22864114
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HEPACAM family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106580.2 → NP_001100050.1  HEPACAM family member 2 precursor

      See identical proteins and their annotated locations for NP_001100050.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168741
      UniProtKB/TrEMBL
      A0A8I5ZP99, B5DEN8
      Related
      ENSRNOP00000080232.2, ENSRNOT00000112288.2
      Conserved Domains (3) summary
      pfam13927
      Location:149 → 224
      Ig_3; Immunoglobulin domain
      cd00096
      Location:167 → 171
      Ig; Ig strand B [structural motif]
      cl11960
      Location:254 → 333
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      32400523..32435936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285722.1 → XP_063141792.1  HEPACAM family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZP99, F7FEX6

    2. XM_063285723.1 → XP_063141793.1  HEPACAM family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZP99, F7FEX6

    3. XM_039107255.2 → XP_038963183.1  HEPACAM family member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZP99, B5DEN8
      Conserved Domains (3) summary
      pfam13927
      Location:149 → 224
      Ig_3; Immunoglobulin domain
      cd00096
      Location:167 → 171
      Ig; Ig strand B [structural motif]
      cl11960
      Location:254 → 333
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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