Shoc2 SHOC2 leucine-rich repeat scaffold protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Shoc2provided by RGD
Official Full Name: SHOC2 leucine-rich repeat scaffold proteinprovided by RGD
Primary source: RGD:1308146
See related: EnsemblRapid:ENSRNOG00000015339 AllianceGenome:RGD:1308146
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein phosphatase 1 binding activity and volume-sensitive anion channel activity. Involved in several processes, including cellular response to growth hormone stimulus; nerve growth factor signaling pathway; and regulation of neuron differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1 and atopic dermatitis. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 206.5), Kidney (RPKM 187.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (262964345..263052898)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (252958939..253048820)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (274700621..274751195)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sur8 is an antidifferentiation factor that stimulates proliferation for maintenance of self-renewal in NPCs via modulation of the Ras-ERK pathway.
Title: Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables volume-sensitive anion channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to growth hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein phosphatase type 1 complex	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 1 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat protein SHOC-2

Names: protein soc-2 homolog; protein sur-8 homolog; soc-2 (suppressor of clear) homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013155.2 → NP_001013173.1 leucine-rich repeat protein SHOC-2

See identical proteins and their annotated locations for NP_001013173.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q6AYI5

UniProtKB/TrEMBL

A6JHX2

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

262964345..263052898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080784.2 → XP_038936712.1 leucine-rich repeat protein SHOC-2 isoform X1

UniProtKB/Swiss-Prot

Q6AYI5

UniProtKB/TrEMBL

A6JHX2

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]
XM_039080785.2 → XP_038936713.1 leucine-rich repeat protein SHOC-2 isoform X1

UniProtKB/Swiss-Prot

Q6AYI5

UniProtKB/TrEMBL

A6JHX2

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]
XM_039080788.2 → XP_038936716.1 leucine-rich repeat protein SHOC-2 isoform X1

UniProtKB/Swiss-Prot

Q6AYI5

UniProtKB/TrEMBL

A6JHX2

Related

ENSRNOP00000020580.5, ENSRNOT00000020580.8

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]
XM_039080777.2 → XP_038936705.1 leucine-rich repeat protein SHOC-2 isoform X1

UniProtKB/Swiss-Prot

Q6AYI5

UniProtKB/TrEMBL

A6JHX2

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]
XM_039080789.2 → XP_038936717.1 leucine-rich repeat protein SHOC-2 isoform X1

UniProtKB/Swiss-Prot

Q6AYI5

UniProtKB/TrEMBL

A6JHX2

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]
XM_063265372.1 → XP_063121442.1 leucine-rich repeat protein SHOC-2 isoform X2