Nadsyn1 NAD synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nadsyn1provided by RGD
Official Full Name: NAD synthetase 1provided by RGD
Primary source: RGD:727801
See related: EnsemblRapid:ENSRNOG00000020736 AllianceGenome:RGD:727801
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAD+ synthase (glutamine-hydrolyzing) activity and glutaminase activity. Predicted to be involved in 'de novo' NAD biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 99.2), Liver (RPKM 61.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (208410914..208439242, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (198981559..199009853, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (216985710..217013743, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI295935 (e-PCR)
- UniSTS:246789

RH134635 (e-PCR)
- UniSTS:217914

UniSTS:235340 (e-PCR)
- UniSTS:235340

RH128514 (e-PCR)
- UniSTS:211822

Osbpl5 (e-PCR), detects polymorphism
- UniSTS:254325

Osbpl5 (e-PCR), detects polymorphism
- UniSTS:526745

Osbp2-pending (e-PCR), detects polymorphism
- UniSTS:209586

AU028969 (e-PCR)
- UniSTS:111819

AI462538 (e-PCR)
- UniSTS:179686

RH130728 (e-PCR)
- UniSTS:214012

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NAD+ synthase (glutamine-hydrolyzing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ synthase (glutamine-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables NAD+ synthase (glutamine-hydrolyzing) activity	ISO Inferred from Sequence Orthology more info
enables NAD+ synthase (glutamine-hydrolyzing) activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' NAD biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 'de novo' NAD biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in NAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamine-dependent NAD(+) synthetase

Names: NAD(+) synthase; NAD(+) synthetase

NP_852145.2

EC 6.3.5.1

XP_063121928.1

EC 6.3.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.