Fam81a family with sequence similarity 81, member A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fam81aprovided by RGD
Official Full Name: family with sequence similarity 81, member Aprovided by RGD
Primary source: RGD:1311958
See related: EnsemblRapid:ENSRNOG00000057501 AllianceGenome:RGD:1311958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311958
Summary: Predicted to enable molecular condensate scaffold activity. Located in postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human FAM81A (family with sequence similarity 81 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 208.1), Kidney (RPKM 195.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (79643754..79702792, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (70762852..70821898, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (76521662..76579387, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

observations firmly establish FAM81A protein as a component of the postsynaptic density in the adult brain, suggesting a role in synaptic function.
Title: FAM81A protein, a novel component of the postsynaptic density in adult brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049501 (e-PCR)
- UniSTS:145948

AU048745 (e-PCR)
- UniSTS:145195

D8Got112 (e-PCR)
- UniSTS:115008

RH137894 (e-PCR)
- UniSTS:219981

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein FAM81A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108163.2 → NP_001101633.1 protein FAM81A

See identical proteins and their annotated locations for NP_001101633.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

A6KEU1, D4A7T8

Related

ENSRNOP00000071796.1, ENSRNOT00000090747.3

Conserved Domains (1) summary

COG1196
Location:76 → 317

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_001433748.1 → NP_001420677.1 protein FAM81A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

A6KEU1, D4A7T8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

79643754..79702792 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243379.5 → XP_006243441.1 protein FAM81A isoform X1

Conserved Domains (1) summary

COG1196
Location:76 → 317

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006243378.5 → XP_006243440.1 protein FAM81A isoform X1

Conserved Domains (1) summary

COG1196
Location:76 → 317

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]