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    Tbca tubulin folding cofactor A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366995, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbcaprovided by RGD
    Official Full Name
    tubulin folding cofactor Aprovided by RGD
    Primary source
    RGD:1311538
    See related
    EnsemblRapid:ENSRNOG00000048342 AllianceGenome:RGD:1311538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in protein folding and tubulin complex assembly. Predicted to be located in nucleolus. Predicted to be active in microtubule cytoskeleton. Orthologous to human TBCA (tubulin folding cofactor A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 608.5), Testes (RPKM 578.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbca in Genome Data Viewer
    Location:
    2q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (27745985..27800624)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (26011714..26065909)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (24449498..24505351)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 3 subunit beta 1 Neighboring gene uncharacterized LOC108349922 Neighboring gene uncharacterized LOC108350223 Neighboring gene orthopedia homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin-specific chaperone A
    Names
    CFA
    TCP1-chaperonin cofactor A
    tubulin cofactor a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013245.3 → NP_001013263.1  tubulin-specific chaperone A

      See identical proteins and their annotated locations for NP_001013263.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q6PEC1
      UniProtKB/TrEMBL
      A0A8I6APW4, A6I4X1
      Conserved Domains (1) summary
      pfam02970
      Location:9 → 95
      TBCA; Tubulin binding cofactor A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      27745985..27800624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282311.1 → XP_063138381.1  tubulin-specific chaperone A isoform X2

    2. XM_039102816.2 → XP_038958744.1  tubulin-specific chaperone A isoform X3

      Conserved Domains (1) summary
      pfam02970
      Location:41 → 87
      TBCA; Tubulin binding cofactor A

    3. XM_063282312.1 → XP_063138382.1  tubulin-specific chaperone A isoform X4

    4. XM_063282310.1 → XP_063138380.1  tubulin-specific chaperone A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZW23
      Related
      ENSRNOP00000084980.2, ENSRNOT00000099853.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEC1.1 GenPept UniProtKB/Swiss-Prot:Q6PEC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools