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    Tafazzin tafazzin, phospholipid-lysophospholipid transacylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tafazzinprovided by RGD
    Official Full Name
    tafazzin, phospholipid-lysophospholipid transacylaseprovided by RGD
    Primary source
    RGD:1588532
    See related
    EnsemblRapid:ENSRNOG00000053023 AllianceGenome:RGD:1588532
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Taz
    Summary
    Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Involved in positive regulation of ATP biosynthetic process and positive regulation of cardiolipin metabolic process. Predicted to be located in mitochondrial inner membrane and mitochondrial outer membrane. Predicted to be active in mitochondrial membrane. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Orthologous to human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: Some orthologs of Taz (Gene ID: 363521) and Wwtr1 (Gene ID: 295062), such as the human and mouse orthologs, share the Taz symbol/alias in common. Taz is a widely used alternative name for WW domain-containing transcription regulator protein 1 (Wwtr1), which can be confused with the official symbol for tafazzin (Taz). [20 Dec 2019]
    Expression
    Biased expression in Heart (RPKM 174.1), Muscle (RPKM 168.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tafazzin in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (157216826..157230524)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (152065539..152076178)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156421006..156429461, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ribosomal protein L10 Neighboring gene deoxyribonuclease 1-like 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 4 Neighboring gene ATPase H+ transporting accessory protein 1 Neighboring gene GDP dissociation inhibitor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tafazzin-dependent cardiolipin composition in C6 glioma cells correlates with changes in mitochondrial and cellular functions, and cellular proliferation. Gürtler S, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Apr. PMID 30639735
    2. Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts. He Q, et al. Am J Physiol Heart Circ Physiol, 2013 Nov 1. PMID 23997105
    3. Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes. He Q. Am J Physiol Heart Circ Physiol, 2010 Jul. PMID 20348225
    4. Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome. Vreken P, et al. Biochem Biophys Res Commun, 2000 Dec 20. PMID 11118295
    5. Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells. Ohlig T, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Apr. PMID 29325722

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results find that knock-out of tafazzin (Taz) changed substantially the profile of fatty acids incorporated in cardiolipin (CL) and the distribution of CL species. It was further associated with decreased capacity of oxidative phosphorylation and switch to glycolysis, altered morphology and arrangement, and reduction in glioma cell proliferation.
      Title: Tafazzin-dependent cardiolipin composition in C6 glioma cells correlates with changes in mitochondrial and cellular functions, and cellular proliferation.
    2. Knock-down of tafazzin had no consequence with respect to the pattern of cellular fatty acids but caused a decrease in cell proliferation.
      Title: Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells.
    3. Tafazzin knockdown interrupts the neonatal ventricular fibroblast cell cycle and this in turn may contribute to fibrosis and dilated cardiomyopathy in Barth syndrome.
      Title: Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts.
    4. Data support the concept that a decreased tafazzin expression causes cardiomyocyte hypertrophy in vitro.
      Title: Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116399

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiolipin acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiolipin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner mitochondrial membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial ATP synthesis coupled electron transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cardiolipin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatocyte division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tafazzin
    Names
    Barth syndrome)
    cardiomyopathy, dilated 3A (X-linked)
    endocardial fibroelastosis 2
    tafazzin (cardiomyopathy, dilated 3A (X-linked)
    tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome)
    NP_001020919.1
    XP_006229661.1
    XP_038955846.1
    XP_038955847.1
    XP_038955848.1
    XP_038955849.1
    XP_038955851.1
    XP_063136233.1
    XP_063136234.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025748.1 → NP_001020919.1  tafazzin

      See identical proteins and their annotated locations for NP_001020919.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099221
      UniProtKB/TrEMBL
      A0A8I6A188, Q4KLG6
      Conserved Domains (1) summary
      cd07989
      Location:34 → 241
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      157216826..157230524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099920.2 → XP_038955848.1  tafazzin isoform X3

      UniProtKB/TrEMBL
      A0A8I6ABG2
      Conserved Domains (1) summary
      cd07989
      Location:34 → 216
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    2. XM_063280164.1 → XP_063136234.1  tafazzin isoform X4

      UniProtKB/TrEMBL
      A0A8I6ABG2, A6KRR5
      Related
      ENSRNOP00000089690.1, ENSRNOT00000112223.2

    3. XM_039099918.2 → XP_038955846.1  tafazzin isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0X0, A0A8I6A188
      Related
      ENSRNOP00000071612.2, ENSRNOT00000089778.3
      Conserved Domains (1) summary
      cd07989
      Location:34 → 242
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    4. XM_006229599.5 → XP_006229661.1  tafazzin isoform X2

      See identical proteins and their annotated locations for XP_006229661.1

      UniProtKB/TrEMBL
      A0A8I6A188, Q4KLG6
      Related
      ENSRNOP00000080949.1, ENSRNOT00000110015.2
      Conserved Domains (1) summary
      cd07989
      Location:34 → 241
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    5. XM_039099919.2 → XP_038955847.1  tafazzin isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0X0, A0A8I6A188
      Conserved Domains (1) summary
      cd07989
      Location:34 → 242
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    6. XM_063280163.1 → XP_063136233.1  tafazzin isoform X2

      UniProtKB/TrEMBL
      A0A8I6A188, Q4KLG6

    7. XM_039099921.2 → XP_038955849.1  tafazzin isoform X5

      UniProtKB/TrEMBL
      A6KRR6
      Conserved Domains (1) summary
      cd07989
      Location:17 → 204
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    8. XM_039099923.2 → XP_038955851.1  tafazzin isoform X6

      Conserved Domains (1) summary
      cd07989
      Location:1 → 111
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    Nucleotide Protein Strain
    Heading Accession and Version

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