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    Kng2l1 kininogen 2-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25087, updated on 9-Dec-2024

    Summary

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    Symbol
    Kng2l1provided by RGD
    Full Name
    kininogen 2-like 1provided by RGD
    Primary source
    RGD:1594590
    See related
    EnsemblRapid:ENSRNOG00000079266 AllianceGenome:RGD:1594590
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kng; Kng1; Kng2; Kngk; KINKG; KINKH; kininogen
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including blood coagulation; negative regulation of peptidase activity; and vasodilation. Predicted to be located in extracellular region and membrane. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Kng2l1 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91483419..91507564)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77978795..78002976)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene kininogen 2 Neighboring gene cyclin B1 interacting protein 1, pseudogene 2 Neighboring gene uncharacterized LOC108352357 Neighboring gene lactate dehydrogenase A, pseudogene 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Strain-specific deletions in exon 10 of rat K-kininogen and T1-kininogen genes allow mapping of both genes to rat chromosome 11. Harris EL, et al. Mamm Genome, 1997 Oct. PMID 9321484
    2. Differing expression patterns and evolution of the rat kininogen gene family. Kitagawa H, et al. J Biol Chem, 1987 Feb 15. PMID 3029068
    3. Structure and expression of the genes for major acute phase alpha 1-protein (thiostatin) and kininogen in the rat. Fung WP, et al. J Biol Chem, 1987 Jul 5. PMID 2439509
    4. Differing utilization of homologous transcription initiation sites of rat K and T kininogen genes under inflammation condition. Kageyama R, et al. J Biol Chem, 1987 Feb 15. PMID 3818598
    5. Primary structures of the mRNAs encoding the rat precursors for bradykinin and T-kinin. Structural relationship of kininogens with major acute phase protein and alpha 1-cysteine proteinase inhibitor. Furuto-Kato S, et al. J Biol Chem, 1985 Oct 5. PMID 2413018

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury.
      Title: Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kininogen-1
    Names
    K-kininogen
    kininogen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102418.1 → NP_001095888.1  kininogen-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001095888.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, and includes an alternate penultimate exon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC088155
      UniProtKB/TrEMBL
      A6JS35, Q5M8A0
      Conserved Domains (2) summary
      smart00043
      Location:264 → 371
      CY; Cystatin-like domain
      pfam00031
      Location:144 → 238
      Cystatin; Cystatin domain

    2. NM_012741.1 → NP_036873.1  kininogen-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_036873.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1)
      Source sequence(s)
      L29428
      UniProtKB/Swiss-Prot
      P08933, P08934
      UniProtKB/TrEMBL
      A0A8I6GER1, A6JS39
      Related
      ENSRNOP00000086253.1, ENSRNOT00000102748.2
      Conserved Domains (2) summary
      smart00043
      Location:264 → 371
      CY; Cystatin-like domain
      pfam00031
      Location:144 → 238
      Cystatin; Cystatin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      91483419..91507564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08934.1 GenPept UniProtKB/Swiss-Prot:P08934

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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