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    Abcg3 ATP binding cassette subfamily G member 3 [ Mus musculus (house mouse) ]

    Gene ID: 27405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abcg3provided by MGI
    Official Full Name
    ATP binding cassette subfamily G member 3provided by MGI
    Primary source
    MGI:MGI:1351624
    See related
    Ensembl:ENSMUSG00000029299 AllianceGenome:MGI:1351624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mxr2; Abcp2
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in thymus adult (RPKM 4.1), spleen adult (RPKM 3.8) and 9 other tissues See more
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    Genomic context

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    See Abcg3 in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105082924..105130675, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104935057..104982811, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13843 Neighboring gene predicted gene, 29714 Neighboring gene STARR-seq mESC enhancer starr_13844 Neighboring gene predicted gene, 29716 Neighboring gene predicted gene, 24097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:105411589-105411825 Neighboring gene STARR-seq mESC enhancer starr_13846 Neighboring gene Sec61 beta subunit pseudogene Neighboring gene guanylate-binding protein 8 Neighboring gene STARR-seq mESC enhancer starr_13847

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain. Mickley L, et al. Mamm Genome, 2001 Jan. PMID 11178751
    2. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Olszewski MA, et al. J Interferon Cytokine Res, 2006 May. PMID 16689661
    3. Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Schriml LM, et al. Genomics, 2000 Feb 15. PMID 10708515
    4. Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains. Wergedal JE, et al. J Lipid Res, 2007 Aug. PMID 17496333
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables riboflavin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in renal urate salt excretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in riboflavin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transepithelial transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family G member 3
    Names
    ATP-binding cassette, sub-family G (WHITE), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419102.1 → NP_001406031.1  ATP-binding cassette sub-family G member 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125005
      UniProtKB/TrEMBL
      D3Z0Z4
      Related
      ENSMUSP00000120179.2, ENSMUST00000130644.2

    2. NM_030239.3 → NP_084515.2  ATP-binding cassette sub-family G member 3 isoform 1

      See identical proteins and their annotated locations for NP_084515.2

      Status: VALIDATED

      Source sequence(s)
      AC125005
      Consensus CDS
      CCDS19488.1
      UniProtKB/Swiss-Prot
      Q8BKI5, Q99P81
      Related
      ENSMUSP00000031239.7, ENSMUST00000031239.13
      Conserved Domains (3) summary
      TIGR00955
      Location:64 → 642
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:372 → 576
      ABC2_membrane; ABC-2 type transporter
      cl21455
      Location:35 → 261
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      105082924..105130675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320905.2 → XP_017176394.1  ATP-binding cassette sub-family G member 3 isoform X1

      Conserved Domains (1) summary
      TIGR00955
      Location:137 → 670
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

    2. XM_017320906.2 → XP_017176395.1  ATP-binding cassette sub-family G member 3 isoform X2

      Conserved Domains (2) summary
      pfam12183
      Location:19 → 71
      NotI; Restriction endonuclease NotI
      cl38936
      Location:108 → 334
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99P81.2 GenPept UniProtKB/Swiss-Prot:Q99P81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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