Cyp8b1 cytochrome P450 family 8 subfamily B member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp8b1provided by RGD
Official Full Name: cytochrome P450 family 8 subfamily B member 1provided by RGD
Primary source: RGD:71016
See related: AllianceGenome:RGD:71016
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables sterol 12-alpha-hydroxylase activity. Involved in response to cholesterol and response to nutrient levels. Predicted to be located in endoplasmic reticulum membrane. Biomarker of extrahepatic cholestasis. Orthologous to human CYP8B1 (cytochrome P450 family 8 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (130455622..130457592, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (121578123..121580093, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (130548418..130550388, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It has been demonstrated that hepatic gene expression of Cyp8b1 is directed by day/night rhythm but not daily rhythm in food intake. Combining an high-fat diet with feeding in the light/inactive period annulled Cyp8b1 gene expression rhythms.
Title: Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats.
Cholesterol loading reduces SREBP-1 mRNA expression in addition to reducing functional SREBP-1 protein, and results in decreasing CYP8B1 gene transcription.
Title: Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables sterol 12-alpha-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol 12-alpha-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol 12-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
involved_in response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Names: cytochrome P450, 8b1, sterol 12 alpha-hydrolase; cytochrome P450, family 8, subfamily b, polypeptide 1

NP_112520.2

EC 1.14.14.139

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031241.2 → NP_112520.2 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I465, G3V8J2, Q9WVT5

Conserved Domains (1) summary

cl41757
Location:55 → 491

cytochrome_P450; cytochrome P450 (CYP) superfamily