Ipo13 importin 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ipo13provided by RGD
Official Full Name: importin 13provided by RGD
Primary source: RGD:620071
See related: EnsemblRapid:ENSRNOG00000019758 AllianceGenome:RGD:620071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lgl2; Imp13
Summary: Enables nuclear glucocorticoid receptor binding activity. Involved in protein import into nucleus. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human IPO13 (importin 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 344.4), Brain (RPKM 131.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (136719204..136740118, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (131433770..131454044, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (136728744..136749187, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that nuclear import of CAR is regulated by importin/Ran-GTP systems.
Title: The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems.
Findings support a role for IPO13 in promoting nuclear occupancy of glucocorticoid receptor in a way that strongly potentiates the antiinflammatory effects of glucocorticoids.
Title: Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear glucocorticoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: importin-13

Names: late gestation lung 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053778.2 → NP_446230.2 importin-13

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9JM04

UniProtKB/TrEMBL

A0A9K3Y899, F1M8G7, Q496Z3

Related

ENSRNOP00000026844.5, ENSRNOT00000026844.8

Conserved Domains (5) summary

smart00913
Location:45 → 109

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:117 → 263

Xpo1; Exportin 1-like protein

pfam18773
Location:402 → 441

Importin_rep; Importin 13 repeat

pfam18786
Location:584 → 627

Importin_rep_2; Importin 13 repeat

pfam18806
Location:826 → 900

Importin_rep_3; Importin 13 repeat