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    Gm12185 predicted gene 12185 [ Mus musculus (house mouse) ]

    Gene ID: 620913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gm12185provided by MGI
    Official Full Name
    predicted gene 12185provided by MGI
    Primary source
    MGI:MGI:3652173
    See related
    Ensembl:ENSMUSG00000048852 AllianceGenome:MGI:3652173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irgb2b1
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly; cellular response to interferon-beta; and innate immune response. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Gm12185 in Genome Data Viewer
    Location:
    11 B1.2; 11 28.89 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48795483..48818009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (48904656..48927182, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9362 Neighboring gene STARR-positive B cell enhancer ABC_E8397 Neighboring gene immunity-related GTPase family M member 1 Neighboring gene predicted gene 5431 Neighboring gene STARR-positive B cell enhancer ABC_E6975 Neighboring gene RIKEN cDNA 9930111J21 gene 1 Neighboring gene protease (prosome, macropain) activator subunit 2B Neighboring gene STARR-positive B cell enhancer mm9_chr11:48793591-48793892 Neighboring gene predicted gene, 42074 Neighboring gene STARR-seq mESC enhancer starr_29366 Neighboring gene T cell specific GTPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice. Murillo-León M, et al. Nat Commun, 2019 Mar 15. PMID 30874554, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6071

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon inducible GTPase
    Names
    Immunity related GTPase, B2-B1 tandem, WSB specific

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045540.2 → NP_001039005.1  interferon inducible GTPase

      See identical proteins and their annotated locations for NP_001039005.1

      Status: VALIDATED

      Source sequence(s)
      AL645849
      Consensus CDS
      CCDS36142.1
      UniProtKB/TrEMBL
      A0A1G5SJB0, Q5NCB2
      Related
      ENSMUSP00000092049.3, ENSMUST00000094476.9
      Conserved Domains (3) summary
      cd04104
      Location:472 → 668
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam05049
      Location:438 → 810
      IIGP; Interferon-inducible GTPase (IIGP)
      cl21455
      Location:61 → 257
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      48795483..48818009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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