U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tex11 testis expressed gene 11 [ Mus musculus (house mouse) ]

    Gene ID: 83558, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tex11provided by MGI
    Official Full Name
    testis expressed gene 11provided by MGI
    Primary source
    MGI:MGI:1933237
    See related
    Ensembl:ENSMUSG00000009670 AllianceGenome:MGI:1933237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZIP4H; 4930565P14Rik
    Summary
    Involved in meiotic gene conversion and reciprocal meiotic recombination. Acts upstream of or within several processes, including male gonad development; meiotic nuclear division; and negative regulation of apoptotic process. Located in central element. Colocalizes with synaptonemal complex. Is expressed in oocyte and testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 2. Orthologous to human TEX11 (testis expressed 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tex11 in Genome Data Viewer
    Location:
    X C3; X 43.72 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99882254..100103245, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100838648..101059639, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47637 Neighboring gene predicted gene 14902 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:97972350-97972459 Neighboring gene discs large MAGUK scaffold protein 3 Neighboring gene STARR-seq mESC enhancer starr_47638 Neighboring gene STARR-seq mESC enhancer starr_47639 Neighboring gene sarcoglycan, beta (dystrophin-associated glycoprotein) pseudogene Neighboring gene predicted gene, 24577 Neighboring gene predicted gene, 27510 Neighboring gene 60S ribosomal protein L37-like Neighboring gene high mobility group protein B1-like Neighboring gene predicted gene 3820

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice. Ghieh F, et al. PLoS One, 2024. PMID 39231187, Free PMC Article
    2. Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatogonial stem cells. Wang YH, et al. Asian J Androl, 2021 Nov-Dec. PMID 33533741, Free PMC Article
    3. ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over. Adelman CA, et al. PLoS Genet, 2008 Mar 28. PMID 18369460, Free PMC Article
    4. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans. Liu C, et al. EMBO J, 2021 Jul 1. PMID 33978233, Free PMC Article
    5. TEX11 modulates germ cell proliferation by competing with estrogen receptor β for the binding to HPIP. Yu YH, et al. Mol Endocrinol, 2012 Apr. PMID 22383461, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice.
      Title: A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice.
    2. Tex11 regulates genome-wide recombination rates in both sexes in a dosage-dependent manner. An intronless autosomal Tex11 transgene functionally substitutes for the X-linked Tex11 gene, providing genetic evidence for the X-to-autosomal retrotransposition evolution phenomenon.
      Title: TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.
    3. mouse spermatogonial stem cells expressed Tex11, Hpip, and Esr2 but not Esr1, and in cultured cells, TEX11 competed with Esr2 for binding to HPIP.
      Title: TEX11 modulates germ cell proliferation by competing with estrogen receptor β for the binding to HPIP.
    4. Tex11 was first identified from mouse spermatogonia and was specifically expressed in mouse testis.
      Title: An abundance of X-linked genes expressed in spermatogonia.
    5. Zip4h (Tex11), a male germ cell specific X-linked gene was isolated. Zip4h(-/Y) mutant mice were fertile. Analysis of spermatocytes revealed a delay in meiotic double strand break repair and decreased crossover formation.
      Title: ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over.
    6. TEX11 promotes initiation and/or maintenance of synapsis and formation of crossovers, and may provide a physical link between these two meiotic processes.
      Title: Meiotic failure in male mice lacking an X-linked factor.
    7. Tex11 forms discrete foci on meiotic chromosomes. Tex11 is essential for meiosis and fertility in males. Tex11 promotes both chromosomal synapsis and crossover formation in mice and may link these two meiotic processes by interacting with Sycp2 in vivo.
      Title: Meiotic failure in male mice lacking an X-linked factor.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic gene conversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of developmental process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within resolution of meiotic recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in central element IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in central element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    testis-expressed protein 11
    Names
    protein ZIP4 homolog
    testis-expressed sequence 11 protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167997.1 → NP_001161469.1  testis-expressed protein 11 isoform 2

      See identical proteins and their annotated locations for NP_001161469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK029799, AK082794
      Consensus CDS
      CCDS53150.1
      UniProtKB/Swiss-Prot
      Q14AT2
      Related
      ENSMUSP00000109345.3, ENSMUST00000113716.3
      Conserved Domains (2) summary
      sd00006
      Location:436 → 472
      TPR; TPR repeat [structural motif]
      pfam08631
      Location:176 → 430
      SPO22; Meiosis protein SPO22/ZIP4 like

    2. NM_031384.2 → NP_113561.2  testis-expressed protein 11 isoform 1

      See identical proteins and their annotated locations for NP_113561.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK029799, BC116709
      Consensus CDS
      CCDS30308.1
      UniProtKB/Swiss-Prot
      Q14AT2, Q8BUS0, Q99MW9
      Related
      ENSMUSP00000009814.4, ENSMUST00000009814.10
      Conserved Domains (2) summary
      sd00006
      Location:436 → 472
      TPR; TPR repeat [structural motif]
      pfam08631
      Location:176 → 430
      SPO22; Meiosis protein SPO22/ZIP4 like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      99882254..100103245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14AT2.1 GenPept UniProtKB/Swiss-Prot:Q14AT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools