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    Lvrn laeverin [ Mus musculus (house mouse) ]

    Gene ID: 74574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lvrnprovided by MGI
    Official Full Name
    laeverinprovided by MGI
    Primary source
    MGI:MGI:1921824
    See related
    Ensembl:ENSMUSG00000024481 AllianceGenome:MGI:1921824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APQ; AP-Q; Aqpep; 4833403I15Rik
    Summary
    Predicted to enable metallopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and skin. Orthologous to human LVRN (laeverin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 1.3), bladder adult (RPKM 0.6) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lvrn in Genome Data Viewer
    Location:
    18 C; 18 24.84 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46983106..47040313)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46848826..46907246)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr18:46901062-46901363 Neighboring gene autophagy related 12 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit Neighboring gene STARR-seq mESC enhancer starr_44521 Neighboring gene STARR-seq mESC enhancer starr_44523 Neighboring gene predicted gene, 23610 Neighboring gene ADP-ribosylation factor-like 14 effector protein-like Neighboring gene STARR-seq mESC enhancer starr_44529 Neighboring gene predicted gene 3744

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lvrn expression is not critical for mouse placentation. Tobita T, et al. J Reprod Dev, 2019 Jun 14. PMID 30745494, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130603

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aminopeptidase Q

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029008.1 → NP_083284.1  aminopeptidase Q

      Status: VALIDATED

      Source sequence(s)
      AC122801, AC132100
      Consensus CDS
      CCDS50284.1
      UniProtKB/TrEMBL
      E9QJR0
      Related
      ENSMUSP00000025358.3, ENSMUST00000025358.4
      Conserved Domains (3) summary
      cd09601
      Location:102 → 575
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:94 → 504
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:646 → 964
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      46983106..47040313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161298.1 → XP_036017191.1  aminopeptidase Q isoform X1

      Conserved Domains (2) summary
      cd09601
      Location:6 → 316
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:391 → 710
      ERAP1_C; ERAP1-like C-terminal domain

    2. XM_036161299.1 → XP_036017192.1  aminopeptidase Q isoform X2

      Conserved Domains (2) summary
      pfam11838
      Location:268 → 587
      ERAP1_C; ERAP1-like C-terminal domain
      cl14813
      Location:1 → 193
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KHK3.3 GenPept UniProtKB/Swiss-Prot:Q2KHK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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