Supv3l1 suppressor of var1, 3-like 1 (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Supv3l1provided by MGI
Official Full Name: suppressor of var1, 3-like 1 (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:2441711
See related: Ensembl:ENSMUSG00000020079 AllianceGenome:MGI:2441711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6330443E10Rik
Summary: Predicted to enable helicase activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial RNA 3'-end processing; mitochondrial RNA surveillance; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrion. Is expressed in several structures, including brain; early embryo; extraembryonic component; sensory organ; and skin. Orthologous to human SUPV3L1 (Suv3 like RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 5.0), CNS E11.5 (RPKM 4.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.4 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62265000..62287294, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62429221..62451515, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUV3 Helicase and Mitochondrial Homeostasis.
Title: SUV3 Helicase and Mitochondrial Homeostasis.
Spatial and temporal aspects of Supv3L1 promoter activity.
Title: Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse.
Supv3L1 is important for the maintenance of the skin barrier. In addition, loss of Supv3L1 function leads to accelerated aging-like phenotypes.
Title: Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
Mice homozygous for Supv3L1 mutation die in utero before midgestation.
Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in DNA duplex unwinding	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA recombination	ISO Inferred from Sequence Orthology more info
involved_in DNA recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial RNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial RNA surveillance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA surveillance	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial mRNA surveillance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial mRNA surveillance	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial ncRNA surveillance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ncRNA surveillance	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial RNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of mitochondrial degradosome	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial degradosome	ISO Inferred from Sequence Orthology more info
part_of mitochondrial degradosome	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP-dependent RNA helicase SUPV3L1, mitochondrial

Names: SUV3-like protein 1; suppressor of var1 3-like protein 1

NP_001346735.1

EC 3.6.4.13

NP_852088.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359806.1 → NP_001346735.1 ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AK031911, AK143755, AW049139, BB859685

Conserved Domains (2) summary

cd00079
Location:112 → 247

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam12513
Location:387 → 433

SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal
NM_181423.3 → NP_852088.1 ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_852088.1

Status: VALIDATED

Source sequence(s)

AK143755, AW049139, BB859685, BC049796

Consensus CDS

CCDS35920.1

UniProtKB/Swiss-Prot

Q50HX5, Q80YD1

Related

ENSMUSP00000020273.10, ENSMUST00000020273.16

Conserved Domains (3) summary

smart00487
Location:187 → 353

DEXDc; DEAD-like helicases superfamily

cd00079
Location:351 → 486

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam12513
Location:626 → 672

SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal