IRF7 interferon regulatory factor 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IRF7provided by HGNC
Official Full Name: interferon regulatory factor 7provided by HGNC
Primary source: HGNC:HGNC:6122
See related: Ensembl:ENSG00000185507 MIM:605047; AllianceGenome:HGNC:6122
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IMD39; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
Summary: This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Broad expression in spleen (RPKM 16.7), lymph node (RPKM 8.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (612555..615950, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (661201..664566, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (612555..615950, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism-related mechanisms.
Title: Single-cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism-related mechanisms.
Non-transcriptional IRF7 interacts with NF-kappaB to inhibit viral inflammation.
Title: Non-transcriptional IRF7 interacts with NF-κB to inhibit viral inflammation.
IRF7: role and regulation in immunity and autoimmunity.
Title: IRF7: role and regulation in immunity and autoimmunity.
Interferon regulatory factor 7 in inflammation, cancer and infection.
Title: Interferon regulatory factor 7 in inflammation, cancer and infection.
Porcine Epidemic Diarrhea Virus Membrane Protein Interacted with IRF7 to Inhibit Type I IFN Production during Viral Infection.
Title: Porcine Epidemic Diarrhea Virus Membrane Protein Interacted with IRF7 to Inhibit Type I IFN Production during Viral Infection.
Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection.
Title: Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection.
ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis.
Title: ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis.
M2 macrophages contribute to cell proliferation and migration of breast cancer.
Title: M2 macrophages contribute to cell proliferation and migration of breast cancer.
RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism.
Title: RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism.
Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway.
Title: Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (121)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 39 MedGen: C4225358 OMIM: 616345 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The interaction of HIV-1 Tat with cellular transcription factors CDK9 and Sp1 is required for Tat activation of MAP2K3-, MAP2K6-, and IRF7-mediated luciferase transcription	PubMed
	tat	MAP2K6 and IRF7 induce HIV-1 Tat-mediated cellular gene modulation through the p38 MAPK/STAT1 pathway in immature dendritic cells and in monocyte-derived macrophages	PubMed
	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFN regulatory factor 7A (IRF7), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed
	tat	SiRNA-mediated inhibition of IRF7 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages	PubMed
	tat	HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells	PubMed
Vpr	vpr	HIV-1 Vpr upregulates the expression of interferon regulatory factor 7 in human monocyte-derived macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH99331 (e-PCR)
- UniSTS:88589

NoName (e-PCR)
- UniSTS:489758

PMC154027P4 (e-PCR)
- UniSTS:271287

NoName (e-PCR)
- UniSTS:494544

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	TAS Traceable Author Statement more info	PubMed
involved_in MDA-5 signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cytoplasmic pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of viral latency	TAS Traceable Author Statement more info	PubMed
involved_in immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin mediated immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of macrophage apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-alpha production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-alpha production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-beta production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of MyD88-dependent toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of MyD88-independent toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of adaptive immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of immune response	TAS Traceable Author Statement more info	PubMed
involved_in regulation of monocyte differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type I interferon production	TAS Traceable Author Statement more info	PubMed
involved_in response to virus	TAS Traceable Author Statement more info	PubMed
involved_in type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IGI Inferred from Genetic Interaction more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome membrane	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon regulatory factor 7

Names: interferon regulatory factor-7H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029106.1 RefSeqGene

Range

5050..8445

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1313

mRNA and Protein(s)

NM_001572.5 → NP_001563.2 interferon regulatory factor 7 isoform a

See identical proteins and their annotated locations for NP_001563.2

Status: REVIEWED

Description

Transcript Variant: This variant (a) has an alternate exon structure in the 5' coding region, resulting in the use of an alternate start codon compared to variant d. The resulting isoform (a) is shorter and has a distinct N-terminus compared to isoform d.

Source sequence(s)

AF076494, BM849172, U53830, U53831, U73036

Consensus CDS

CCDS7703.1

UniProtKB/Swiss-Prot

B9EGL3, O00331, O00332, O00333, O75924, Q92985, Q9UE79

Related

ENSP00000434009.2, ENST00000525445.6

Conserved Domains (2) summary

pfam00605
Location:13 → 124

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:289 → 466

IRF-3; Interferon-regulatory factor 3
NM_004029.4 → NP_004020.1 interferon regulatory factor 7 isoform b

See identical proteins and their annotated locations for NP_004020.1

Status: REVIEWED

Description

Transcript Variant: This variant (b) has an alternate exon structure in the 5' coding region and lacks an alternate in-frame exon, compared to variant d. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform d.

Source sequence(s)

AF076494, BM849172, U53831

Consensus CDS

CCDS7704.1

Related

ENSP00000331803.9, ENST00000348655.11

Conserved Domains (2) summary

pfam00605
Location:13 → 124

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:260 → 437

IRF-3; Interferon-regulatory factor 3
NM_004031.4 → NP_004022.2 interferon regulatory factor 7 isoform d

See identical proteins and their annotated locations for NP_004022.2

Status: REVIEWED

Description

Transcript Variant: This variant (d) encodes the longest isoform (d).

Source sequence(s)

AF076494, BM849172, U53830, U53831, U73036

Consensus CDS

CCDS7705.1

UniProtKB/Swiss-Prot

Q92985

Related

ENSP00000329411.5, ENST00000330243.9

Conserved Domains (2) summary

pfam00605
Location:26 → 137

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:302 → 479

IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

612555..615950 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011520066.4 → XP_011518368.1 interferon regulatory factor 7 isoform X2

See identical proteins and their annotated locations for XP_011518368.1

Conserved Domains (2) summary

pfam00605
Location:13 → 124

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:288 → 465

IRF-3; Interferon-regulatory factor 3
XM_005252907.4 → XP_005252964.1 interferon regulatory factor 7 isoform X1

See identical proteins and their annotated locations for XP_005252964.1

Conserved Domains (2) summary

pfam00605
Location:26 → 137

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:301 → 478

IRF-3; Interferon-regulatory factor 3
XM_005252909.4 → XP_005252966.1 interferon regulatory factor 7 isoform X3

See identical proteins and their annotated locations for XP_005252966.1

UniProtKB/TrEMBL

A0A1P8DYP2, M9RSF4

Related

ENSP00000380700.2, ENST00000397570.5

Conserved Domains (2) summary

pfam00605
Location:26 → 137

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:273 → 450

IRF-3; Interferon-regulatory factor 3
XM_017017674.1 → XP_016873163.1 interferon regulatory factor 7 isoform X4

UniProtKB/TrEMBL

B4E1B1

Conserved Domains (1) summary

pfam10401
Location:1 → 173

IRF-3; Interferon-regulatory factor 3

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187586.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

142448..145849 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328902.1 → XP_054184877.1 interferon regulatory factor 7 isoform X6
XM_054328899.1 → XP_054184874.1 interferon regulatory factor 7 isoform X2
XM_054328901.1 → XP_054184876.1 interferon regulatory factor 7 isoform X5

UniProtKB/TrEMBL

A0A1P8DYP2
XM_054328898.1 → XP_054184873.1 interferon regulatory factor 7 isoform X1
XM_054328900.1 → XP_054184875.1 interferon regulatory factor 7 isoform X3

UniProtKB/TrEMBL

A0A1P8DYP2, M9RSF4
XM_054328903.1 → XP_054184878.1 interferon regulatory factor 7 isoform X4

UniProtKB/TrEMBL

B4E1B1

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

661201..664566 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054368690.1 → XP_054224665.1 interferon regulatory factor 7 isoform X8
XM_054368687.1 → XP_054224662.1 interferon regulatory factor 7 isoform X2
XM_054368689.1 → XP_054224664.1 interferon regulatory factor 7 isoform X7

UniProtKB/TrEMBL

A0A1P8DYP2
XM_054368686.1 → XP_054224661.1 interferon regulatory factor 7 isoform X1
XM_054368688.1 → XP_054224663.1 interferon regulatory factor 7 isoform X3

UniProtKB/TrEMBL

A0A1P8DYP2
XM_054368691.1 → XP_054224666.1 interferon regulatory factor 7 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_004030.1: Suppressed sequence

Description

NM_004030.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.