PABPC4 poly(A) binding protein cytoplasmic 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PABPC4provided by HGNC
Official Full Name: poly(A) binding protein cytoplasmic 4provided by HGNC
Primary source: HGNC:HGNC:8557
See related: Ensembl:ENSG00000090621 MIM:603407; AllianceGenome:HGNC:8557
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APP1; APP-1; PABP4; iPABP
Summary: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. [provided by RefSeq, Nov 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in testis (RPKM 55.5), ovary (RPKM 46.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (39560816..39576790, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (39429194..39445168, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (40026488..40042462, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy.
Title: PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy.
A novel long non-coding RNA RP11-286H15.1 represses hepatocellular carcinoma progression by promoting ubiquitination of PABPC4.
Title: A novel long non-coding RNA RP11-286H15.1 represses hepatocellular carcinoma progression by promoting ubiquitination of PABPC4.
Gene variants of coagulation related proteins that interact with SARS-CoV-2.
Title: Gene variants of coagulation related proteins that interact with SARS-CoV-2.
The PABPC4 rs4660293 SNP is associated with serum lipid levels.
Title: Gender-specific association between the cytoplasmic poly(A) binding protein 4 rs4660293 single nucleotide polymorphism and serum lipid levels.
although function of PABPN1 may be compensated by nuclear translocation of PABP4 and perhaps by increase the cytoplasmic abundance of PABP5, these were not sufficient to prevent apoptosis of cells. PABPN1 may have an anti apoptotic role in mammalian cells
Title: Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells.
PABPC4 is highly expressed in human colorectal cancer.
Title: Cytoplasmic poly(A) binding protein 4 is highly expressed in human colorectal cancer and correlates with better prognosis.
Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export
Title: Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs.
RNA binding masks nuclear import signals within the cytoplasmic poly(A) binding protein RNA recognition motifs, thereby ensuring ef fi cient cytoplasmic retention of this protein in normal cells
Title: Importin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletion.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify cytoplasmic poly(A) binding protein 4 (PABPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify cytoplasmic poly(A) binding protein 4 (PABPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify cytoplasmic poly(A) binding protein 4 (PABPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify cytoplasmic poly(A) binding protein 4 (PABPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
retropepsin	gag-pol	HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly(A)-dependent translation. However, PABP cleavage has little impact on the translation of polyadenylated encephalomyocarditis virus internal ribosome entry site-containing mRNAs	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:486701

D1S2022E (e-PCR)
- UniSTS:151412

WI-19844 (e-PCR)
- UniSTS:73589

D20S1124 (e-PCR)
- UniSTS:63649

G49186 (e-PCR)
- UniSTS:108965

RH39552 (e-PCR)
- UniSTS:90278

A001T47 (e-PCR)
- UniSTS:20920

PABPC4 (e-PCR)
- UniSTS:503230

MARC_12901-12902:999887268:1 (e-PCR)
- UniSTS:267474

SHGC-84579 (e-PCR)
- UniSTS:102909

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables poly(C) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in RNA processing	TAS Traceable Author Statement more info	PubMed
involved_in blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in myeloid cell development	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info
involved_in translation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polyadenylate-binding protein 4

Names: PABP-4; activated-platelet protein 1; inducible poly(A)-binding protein; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135653.2 → NP_001129125.1 polyadenylate-binding protein 4 isoform 1

See identical proteins and their annotated locations for NP_001129125.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC029969, BC094755

Consensus CDS

CCDS44115.1

UniProtKB/TrEMBL

Q6IQ30

Related

ENSP00000361949.3, ENST00000372858.8

Conserved Domains (1) summary

TIGR01628
Location:11 → 640

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
NM_001135654.2 → NP_001129126.1 polyadenylate-binding protein 4 isoform 3

See identical proteins and their annotated locations for NP_001129126.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

BC029969, BC065540, DB455681

Consensus CDS

CCDS44114.1

UniProtKB/TrEMBL

A0A7I2V4L7

Related

ENSP00000361947.3, ENST00000372856.7

Conserved Domains (1) summary

TIGR01628
Location:11 → 611

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
NM_003819.4 → NP_003810.1 polyadenylate-binding protein 4 isoform 2

See identical proteins and their annotated locations for NP_003810.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform 2 lacks an internal segment, as compared to isoform 1.

Source sequence(s)

BC029969, BC094755, DB455681, U33818

Consensus CDS

CCDS438.1

UniProtKB/Swiss-Prot

B1ANQ8, Q13310, Q4VC03, Q6P0N3

UniProtKB/TrEMBL

Q6IQ30

Related

ENSP00000361948.3, ENST00000372857.7

Conserved Domains (1) summary

TIGR01628
Location:11 → 624

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family