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    HRH3 histamine receptor H3 [ Homo sapiens (human) ]

    Gene ID: 11255, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HRH3provided by HGNC
    Official Full Name
    histamine receptor H3provided by HGNC
    Primary source
    HGNC:HGNC:5184
    See related
    Ensembl:ENSG00000101180 MIM:604525; AllianceGenome:HGNC:5184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HH3R; GPCR97
    Summary
    Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 2.9), testis (RPKM 0.2) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HRH3 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62214960..62220278, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64006090..64011408, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60790016..60795334, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13101 Neighboring gene Sharpr-MPRA regulatory region 1753 Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:60735092-60736291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60736587-60737199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13102 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:60757942-60758126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13103 Neighboring gene mitochondrial ribosome associated GTPase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60789379-60789879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60803162-60804062 Neighboring gene uncharacterized LOC105369209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60814402-60815326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60818849-60819457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60819458-60820065 Neighboring gene oxysterol binding protein like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60831784-60832284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60853989-60854489

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recovery of the histamine H(3) receptor activity lost in yeast cells through error-prone PCR and in vivo selection. Watanabe A, et al. Sci Rep, 2023 Sep 26. PMID 37752220, Free PMC Article
    2. Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders. Esbenshade TA, et al. Mol Interv, 2006 Apr. PMID 16565470
    3. The histamine H3 receptor: from gene cloning to H3 receptor drugs. Leurs R, et al. Nat Rev Drug Discov, 2005 Feb. PMID 15665857
    4. Histamine H3-receptor isoforms. Bakker RA. Inflamm Res, 2004 Oct. PMID 15597144
    5. Altered histamine H3 receptor radioligand binding in post-mortem brain samples from subjects with psychiatric diseases. Jin CY, et al. Br J Pharmacol, 2009 May. PMID 19413576, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recovery of the histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection.
      Title: Recovery of the histamine H(3) receptor activity lost in yeast cells through error-prone PCR and in vivo selection.
    2. Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
      Title: Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
    3. Histamine H3 receptor gene variants associated with drug abuse in patients with cocaine use disorder.
      Title: Histamine H(3) receptor gene variants associated with drug abuse in patients with cocaine use disorder.
    4. Histamine, histamine H3 receptor, and alcohol use disorder.
      Title: Histamine, histamine H(3) receptor, and alcohol use disorder.
    5. These findings revealed that HRH3 serves an important role in the growth and metastasis of hepatocellular carcinomacells, which provides experimental evidence supporting the application of HRH3 as a potential therapeutic target in hepatocellular carcinoma treatment
      Title: Upregulated histamine receptor H3 promotes tumor growth and metastasis in hepatocellular carcinoma.
    6. These results indicate that in SH-SY5Y cells, hH3R445 and hH3R365 isoforms regulate in a differential manner the signaling pathways triggered by receptor activation.
      Title: Differential expression and signaling of the human histamine H(3) receptor isoforms of 445 and 365 amino acids expressed in human neuroblastoma SH-SY5Y cells.
    7. results indicate that the single-point Y197C mutation, in the aminus region of TM5 of the hH3R445, does not affect the expression, ligand binding or signaling of the receptor
      Title: The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H(3) receptor.
    8. We detected high H3R expression in oligodendroglial cells from demyelination lesions in human samples of patients with MS, and validated a genetic association between an exonic single nucleotide polymorphism in HRH3 and susceptibility to multiple sclerosis.
      Title: Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination.
    9. These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population
      Title: Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
    10. Decrease in histamine H3 receptor function was linked to epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant mesial temporal lobe epilepsy.
      Title: Pharmacoresistant temporal lobe epilepsy modifies histamine turnover and H3 receptor function in the human hippocampus and temporal neocortex.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histamine H3 receptor
    Names
    G protein-coupled receptor 97
    H3R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007232.3 → NP_009163.2  histamine H3 receptor

      See identical proteins and their annotated locations for NP_009163.2

      Status: VALIDATED

      Source sequence(s)
      AL078633
      Consensus CDS
      CCDS13493.1
      UniProtKB/Swiss-Prot
      Q4QRI7, Q9GZX2, Q9H4K8, Q9Y5N1
      UniProtKB/TrEMBL
      Q548M6
      Related
      ENSP00000342560.5, ENST00000340177.10
      Conserved Domains (1) summary
      pfam00001
      Location:51 → 412
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      62214960..62220278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027623.2 → XP_016883112.2  histamine H3 receptor isoform X2

      UniProtKB/TrEMBL
      Q548M6

    2. XM_005260266.4 → XP_005260323.1  histamine H3 receptor isoform X1

      See identical proteins and their annotated locations for XP_005260323.1

      UniProtKB/TrEMBL
      Q548M6
      Related
      ENSP00000321482.7, ENST00000317393.10
      Conserved Domains (1) summary
      pfam00001
      Location:51 → 412
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      64006090..64011408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322917.1 → XP_054178892.1  histamine H3 receptor isoform X2

      UniProtKB/TrEMBL
      Q548M6

    2. XM_054322916.1 → XP_054178891.1  histamine H3 receptor isoform X1

      UniProtKB/TrEMBL
      Q548M6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5N1.2 GenPept UniProtKB/Swiss-Prot:Q9Y5N1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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