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    ART3 ADP-ribosyltransferase 3 (inactive) [ Homo sapiens (human) ]

    Gene ID: 419, updated on 10-Dec-2024

    Summary

    Official Symbol
    ART3provided by HGNC
    Official Full Name
    ADP-ribosyltransferase 3 (inactive)provided by HGNC
    Primary source
    HGNC:HGNC:725
    See related
    Ensembl:ENSG00000156219 MIM:603086; AllianceGenome:HGNC:725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARTC3
    Summary
    This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Biased expression in testis (RPKM 18.7) and heart (RPKM 6.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ART3 in Genome Data Viewer
    Location:
    4q21.1; 4p15.1-p14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (76011190..76112786)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (79351693..79453452)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76932343..77033939)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene SDAD1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76932273-76932917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:76938237-76938736 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene ribosomal protein L36 pseudogene 8 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene NANOG hESC enhancer GRCh37_chr4:77016693-77017194 Neighboring gene nucleoporin 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21626 Neighboring gene uncharacterized LOC124900718 Neighboring gene NANOG hESC enhancer GRCh37_chr4:77075501-77076330 Neighboring gene scavenger receptor class B member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26404

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ecto-ADP-ribosyltransferase 3
    Names
    ADP-ribosyltransferase C2 and C3 toxin-like 3
    NAD(P)(+)--arginine ADP-ribosyltransferase 3
    mono(ADP-ribosyl)transferase 3
    mono-ADP-ribosyltransferase
    NP_001123488.1
    NP_001123489.1
    NP_001170.2
    NP_001364102.1
    NP_001364103.1
    NP_001364104.1
    NP_001364105.1
    NP_001364106.1
    NP_001364107.1
    NP_001364108.1
    NP_001364109.1
    NP_001364110.1
    NP_001364111.1
    NP_001364112.1
    NP_001364113.1
    NP_001364114.1
    XP_016863695.1
    XP_024309818.1
    XP_024309819.1
    XP_024309820.1
    XP_024309821.1
    XP_024309822.1
    XP_024309824.1
    XP_024309826.1
    XP_024309827.1
    XP_024309829.1
    XP_024309830.1
    XP_024309831.1
    XP_047271651.1
    XP_047271652.1
    XP_047271653.1
    XP_047271654.1
    XP_047271655.1
    XP_047271656.1
    XP_054206006.1
    XP_054206007.1
    XP_054206008.1
    XP_054206009.1
    XP_054206010.1
    XP_054206011.1
    XP_054206012.1
    XP_054206013.1
    XP_054206014.1
    XP_054206015.1
    XP_054206016.1
    XP_054206017.1
    XP_054206018.1
    XP_054206019.1
    XP_054206020.1
    XP_054206021.1
    XP_054206022.1
    XP_054206023.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130016.3NP_001123488.1  ecto-ADP-ribosyltransferase 3 isoform a precursor

      See identical proteins and their annotated locations for NP_001123488.1

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS47079.1
      UniProtKB/Swiss-Prot
      Q13508, Q53XW3, Q6FHT7, Q8WVJ7, Q93069, Q96HL1
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Related
      ENSP00000348064.4, ENST00000355810.9
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    2. NM_001130017.3NP_001123489.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

      See identical proteins and their annotated locations for NP_001123489.1

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS47080.1
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Related
      ENSP00000343843.5, ENST00000341029.9
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    3. NM_001179.6NP_001170.2  ecto-ADP-ribosyltransferase 3 isoform b precursor

      See identical proteins and their annotated locations for NP_001170.2

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS3575.1
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Related
      ENSP00000304313.5, ENST00000349321.7
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    4. NM_001377173.1NP_001364102.1  ecto-ADP-ribosyltransferase 3 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS93546.1
      UniProtKB/TrEMBL
      H0Y8V6
      Related
      ENSP00000422249.2, ENST00000511188.2
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    5. NM_001377174.1NP_001364103.1  ecto-ADP-ribosyltransferase 3 isoform l precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    6. NM_001377175.1NP_001364104.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS47080.1
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    7. NM_001377176.1NP_001364105.1  ecto-ADP-ribosyltransferase 3 isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    8. NM_001377177.1NP_001364106.1  ecto-ADP-ribosyltransferase 3 isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    9. NM_001377178.1NP_001364107.1  ecto-ADP-ribosyltransferase 3 isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    10. NM_001377179.1NP_001364108.1  ecto-ADP-ribosyltransferase 3 isoform g precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    11. NM_001377180.1NP_001364109.1  ecto-ADP-ribosyltransferase 3 isoform h precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    12. NM_001377181.1NP_001364110.1  ecto-ADP-ribosyltransferase 3 isoform i precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    13. NM_001377182.1NP_001364111.1  ecto-ADP-ribosyltransferase 3 isoform i precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    14. NM_001377183.1NP_001364112.1  ecto-ADP-ribosyltransferase 3 isoform j precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    15. NM_001377184.1NP_001364113.1  ecto-ADP-ribosyltransferase 3 isoform j precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    16. NM_001377185.1NP_001364114.1  ecto-ADP-ribosyltransferase 3 isoform k precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      76011190..76112786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047415697.1XP_047271653.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQ78
    2. XM_047415700.1XP_047271656.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
    3. XM_047415695.1XP_047271651.1  ecto-ADP-ribosyltransferase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TQ78
    4. XM_047415696.1XP_047271652.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQ78
    5. XM_047415699.1XP_047271655.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
    6. XM_047415698.1XP_047271654.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQ78
    7. XM_024454063.2XP_024309831.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    8. XM_024454053.2XP_024309821.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    9. XM_024454052.2XP_024309820.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    10. XM_017008206.3XP_016863695.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    11. XM_024454051.2XP_024309819.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    12. XM_024454062.2XP_024309830.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
      Related
      ENSP00000514989.1, ENST00000700440.1
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    13. XM_024454056.2XP_024309824.1  ecto-ADP-ribosyltransferase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    14. XM_024454058.2XP_024309826.1  ecto-ADP-ribosyltransferase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    15. XM_024454059.2XP_024309827.1  ecto-ADP-ribosyltransferase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    16. XM_024454061.2XP_024309829.1  ecto-ADP-ribosyltransferase 3 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQ78
      Related
      ENSP00000514990.1, ENST00000700441.1
      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    17. XM_024454050.2XP_024309818.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase
    18. XM_024454054.2XP_024309822.1  ecto-ADP-ribosyltransferase 3 isoform X2

      Conserved Domains (1) summary
      pfam01129
      Location:29252
      ART; NAD:arginine ADP-ribosyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      79351693..79453452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350042.1XP_054206017.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQ78
    2. XM_054350047.1XP_054206022.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
    3. XM_054350038.1XP_054206013.1  ecto-ADP-ribosyltransferase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TQ78
    4. XM_054350041.1XP_054206016.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQ78
    5. XM_054350046.1XP_054206021.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
    6. XM_054350043.1XP_054206018.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQ78
    7. XM_054350048.1XP_054206023.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
    8. XM_054350035.1XP_054206010.1  ecto-ADP-ribosyltransferase 3 isoform X1

    9. XM_054350032.1XP_054206007.1  ecto-ADP-ribosyltransferase 3 isoform X1

    10. XM_054350033.1XP_054206008.1  ecto-ADP-ribosyltransferase 3 isoform X1

    11. XM_054350031.1XP_054206006.1  ecto-ADP-ribosyltransferase 3 isoform X1

    12. XM_054350045.1XP_054206020.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
    13. XM_054350037.1XP_054206012.1  ecto-ADP-ribosyltransferase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TQ78
    14. XM_054350039.1XP_054206014.1  ecto-ADP-ribosyltransferase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQ78
    15. XM_054350040.1XP_054206015.1  ecto-ADP-ribosyltransferase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQ78
    16. XM_054350044.1XP_054206019.1  ecto-ADP-ribosyltransferase 3 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQ78
    17. XM_054350034.1XP_054206009.1  ecto-ADP-ribosyltransferase 3 isoform X1

    18. XM_054350036.1XP_054206011.1  ecto-ADP-ribosyltransferase 3 isoform X2