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    B4GALT1-AS1 B4GALT1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 101929639, updated on 10-Dec-2024

    Summary

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    Official Symbol
    B4GALT1-AS1provided by HGNC
    Official Full Name
    B4GALT1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:49910
    See related
    Ensembl:ENSG00000233554 AllianceGenome:HGNC:49910
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 7.8), fat (RPKM 3.3) and 22 other tissues See more
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    Genomic context

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    See B4GALT1-AS1 in Genome Data Viewer
    Location:
    9p21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33166948..33179983)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33185581..33198676)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33166946..33179981)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33111589-33112188 Neighboring gene beta-1,4-galactosyltransferase 1 Neighboring gene microRNA 12117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28273 Neighboring gene uncharacterized LOC124902141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33161108-33162102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33163497-33163996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33167185-33167750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33167751-33168315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33172776-33173276 Neighboring gene RNA, U4atac small nuclear 15, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28287 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:33233401-33234600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28288 Neighboring gene serine peptidase inhibitor Kazal type 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19833 Neighboring gene BAG cochaperone 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. lncRNA B4GALT1-AS1 promotes colon cancer cell stemness and migration by recruiting YAP to the nucleus and enhancing YAP transcriptional activity. Zhang Y, et al. J Cell Physiol, 2019 Aug. PMID 30912138
    2. Multifaceted roles of 5'-regulatory region of the cancer associated gene B4GALT1 and its comparison with the gene family. Al-Obaide MA, et al. Int J Oncol, 2015 Oct. PMID 26315939
    3. LncRNA B4GALT1-AS1 recruits HuR to promote osteosarcoma cells stemness and migration via enhancing YAP transcriptional activity. Li Z, et al. Cell Prolif, 2018 Dec. PMID 30182452, Free PMC Article
    4. Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method. Oshikawa M, et al. DNA Res, 2008 Jun 30. PMID 18487259, Free PMC Article
    5. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Köttgen A, et al. Nat Genet, 2013 Feb. PMID 23263486, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results identify the direct binding of long noncoding RNA B4GALT1-AS1 to YAP, which is responsible for colon cancer cell stemness.
      Title: lncRNA B4GALT1-AS1 promotes colon cancer cell stemness and migration by recruiting YAP to the nucleus and enhancing YAP transcriptional activity.
    2. B4GALT1-AS1 recruited HuR to enhance YAP mRNA stability and thus its transcriptional activity
      Title: LncRNA B4GALT1-AS1 recruits HuR to promote osteosarcoma cells stemness and migration via enhancing YAP transcriptional activity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_108108.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL161445, HY028011, HY043002
      Related
      ENST00000729827.1

    2. NR_108109.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' structure and is shorter compared to variant 1.
      Source sequence(s)
      AL161445, HY143413

    3. NR_108110.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate exons and the 5' and central region and is shorter compared to variant 1.
      Source sequence(s)
      AB371488, AL161445
      Related
      ENST00000426270.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33166948..33179983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33185581..33198676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials