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    Nbea neurobeachin [ Mus musculus (house mouse) ]

    Gene ID: 26422, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nbeaprovided by MGI
    Official Full Name
    neurobeachinprovided by MGI
    Primary source
    MGI:MGI:1347075
    See related
    Ensembl:ENSMUSG00000027799 AllianceGenome:MGI:1347075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lyst2; mKIAA1544
    Summary
    Enables protein kinase binding activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and synapse organization. Acts upstream of or within hematopoietic stem cell homeostasis and protein localization. Located in several cellular components, including cytosol; nucleus; and trans-Golgi network. Is active in glutamatergic synapse. Is expressed in several structures, including brain; genitourinary system; gut; neural tube; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NBEA (neurobeachin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 19.0), whole brain E14.5 (RPKM 15.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nbea in Genome Data Viewer
    Location:
    3 C; 3 26.61 cM
    Exon count:
    66
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (55532616..56091169, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (55625195..56183748, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene STARR-seq mESC enhancer starr_07698 Neighboring gene STARR-seq mESC enhancer starr_07699 Neighboring gene STARR-seq mESC enhancer starr_07700 Neighboring gene predicted gene, 25404 Neighboring gene predicted gene 43549 Neighboring gene STARR-seq mESC enhancer starr_07702 Neighboring gene predicted gene, 46804 Neighboring gene STARR-seq mESC enhancer starr_07703 Neighboring gene STARR-seq mESC enhancer starr_07704 Neighboring gene mab-21-like 1 Neighboring gene SEC13 homolog pseudogene Neighboring gene microRNA 12194 Neighboring gene predicted gene, 31914 Neighboring gene predicted gene, 22784 Neighboring gene STARR-seq mESC enhancer starr_07707 Neighboring gene STARR-seq mESC enhancer starr_07708 Neighboring gene predicted gene, 40052 Neighboring gene predicted gene, 40053

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neurobeachin is essential for neuromuscular synaptic transmission. Su Y, et al. J Neurosci, 2004 Apr 7. PMID 15071111, Free PMC Article
    2. Neurobeachin haploinsufficient mice display sex-independent alterations in cued and contextual fear conditioning. Budniok S, et al. Neuroreport, 2023 Sep 6. PMID 37506311
    3. Dendritic spine formation and synaptic function require neurobeachin. Niesmann K, et al. Nat Commun, 2011 Nov 22. PMID 22109531, Free PMC Article
    4. Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin. Muellerleile J, et al. Sci Rep, 2020 Sep 29. PMID 32994505, Free PMC Article
    5. Post-weaning infant-to-mother bonding in nutritionally independent female mice. Stroobants S, et al. PLoS One, 2020. PMID 31940385, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurobeachin haploinsufficient mice display sex-independent alterations in cued and contextual fear conditioning.
      Title: Neurobeachin haploinsufficient mice display sex-independent alterations in cued and contextual fear conditioning.
    2. Nbea heterozygotes showed normal fear acquisition and fear memory recall but showed impairment in extinction. Our data suggest that NBEA is necessary either for induction of memory lability or for the physiological process of memory extinction
      Title: The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory.
    3. KIF21B constrains NBEA dynamics and is present in the NBEA-recycling endosome-NMDA receptor complex.
      Title: Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.
    4. Nbea targets glutamate and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins.
      Title: Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.
    5. The physical interaction of NBEA with NOTCH1 is most relevant for autism spectrum disorders pathogenesis because NOTCH signaling is essential for neural development.
      Title: Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription.
    6. These findings indicate that Nbea haploinsufficiency leads to various molecular and cellular changes that affect neuroplasticity and behavioral functions in mice
      Title: Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice.
    7. Nbea regulates synaptic transmission under basal conditions by targeting neurotransmitter receptors to synapses.
      Title: Neurobeachin regulates neurotransmitter receptor trafficking to synapses.
    8. Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.
      Title: Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.
    9. data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits
      Title: Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
    10. Data show that deletion of Nbea leads to reduced numbers of spinous synapses in cultured neurons from complete knockouts and in cortical tissue from heterozygous mice, accompanied by altered miniature postsynaptic currents.
      Title: Dendritic spine formation and synaptic function require neurobeachin.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase A binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cerebellar Golgi cell to granule cell synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extrinsic component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurobeachin
    Names
    lysosomal trafficking regulator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030595.1 → NP_085098.1  neurobeachin

      See identical proteins and their annotated locations for NP_085098.1

      Status: VALIDATED

      Source sequence(s)
      AC121842, AC138738, AC162280, BC034103, Y18276
      Consensus CDS
      CCDS50911.1
      UniProtKB/Swiss-Prot
      Q8C931, Q9EPM9, Q9EPN0, Q9EPN1, Q9WVM9
      Related
      ENSMUSP00000029374.7, ENSMUST00000029374.8
      Conserved Domains (8) summary
      COG2319
      Location:2625 → 2924
      WD40; WD40 repeat [General function prediction only]
      pfam02138
      Location:2277 → 2553
      Beach; Beige/BEACH domain
      pfam06469
      Location:1956 → 2122
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2148 → 2245
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      sd00039
      Location:2714 → 2768
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:2667 → 2924
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      55532616..56091169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163118.1 → XP_036019011.1  neurobeachin isoform X14

      Conserved Domains (7) summary
      sd00039
      Location:2705 → 2759
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2268 → 2544
      Beach; Beige/BEACH domain
      pfam06469
      Location:1947 → 2113
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2139 → 2236
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2658 → 2915
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_036163115.1 → XP_036019008.1  neurobeachin isoform X5

      Conserved Domains (7) summary
      sd00039
      Location:2737 → 2791
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2279 → 2576
      Beach; Beige/BEACH domain
      pfam06469
      Location:1947 → 2113
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2150 → 2247
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2690 → 2947
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_017319586.2 → XP_017175075.1  neurobeachin isoform X11

      Conserved Domains (7) summary
      sd00039
      Location:2711 → 2765
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2274 → 2550
      Beach; Beige/BEACH domain
      pfam06469
      Location:1953 → 2119
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2145 → 2242
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2664 → 2921
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_006501520.4 → XP_006501583.1  neurobeachin isoform X7

      Conserved Domains (7) summary
      sd00039
      Location:2732 → 2786
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2274 → 2571
      Beach; Beige/BEACH domain
      pfam06469
      Location:1953 → 2119
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2145 → 2242
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2685 → 2942
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_036163112.1 → XP_036019005.1  neurobeachin isoform X2

      Conserved Domains (7) summary
      sd00039
      Location:2743 → 2797
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2285 → 2582
      Beach; Beige/BEACH domain
      pfam06469
      Location:1953 → 2119
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2156 → 2253
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2696 → 2953
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_017319587.2 → XP_017175076.1  neurobeachin isoform X13

      Conserved Domains (7) summary
      sd00039
      Location:2708 → 2762
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2271 → 2547
      Beach; Beige/BEACH domain
      pfam06469
      Location:1950 → 2116
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2142 → 2239
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2661 → 2918
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_006501522.4 → XP_006501585.1  neurobeachin isoform X8

      Conserved Domains (7) summary
      sd00039
      Location:2729 → 2783
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2271 → 2568
      Beach; Beige/BEACH domain
      pfam06469
      Location:1950 → 2116
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2142 → 2239
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2682 → 2939
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_036163114.1 → XP_036019007.1  neurobeachin isoform X4

      Conserved Domains (7) summary
      sd00039
      Location:2740 → 2794
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2282 → 2579
      Beach; Beige/BEACH domain
      pfam06469
      Location:1950 → 2116
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2153 → 2250
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2693 → 2950
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_006501523.4 → XP_006501586.1  neurobeachin isoform X12

      See identical proteins and their annotated locations for XP_006501586.1

      UniProtKB/Swiss-Prot
      Q9EPN1
      Conserved Domains (7) summary
      sd00039
      Location:2709 → 2763
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2277 → 2553
      Beach; Beige/BEACH domain
      pfam06469
      Location:1956 → 2122
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2148 → 2245
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2662 → 2919
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_006501519.4 → XP_006501582.1  neurobeachin isoform X6

      Conserved Domains (7) summary
      sd00039
      Location:2735 → 2789
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2277 → 2574
      Beach; Beige/BEACH domain
      pfam06469
      Location:1956 → 2122
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2148 → 2245
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2688 → 2945
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_036163117.1 → XP_036019010.1  neurobeachin isoform X10

      Conserved Domains (7) summary
      sd00039
      Location:2720 → 2774
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2288 → 2564
      Beach; Beige/BEACH domain
      pfam06469
      Location:1956 → 2122
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2159 → 2256
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2673 → 2930
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_036163116.1 → XP_036019009.1  neurobeachin isoform X9

      Conserved Domains (7) summary
      sd00039
      Location:2725 → 2779
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2288 → 2564
      Beach; Beige/BEACH domain
      pfam06469
      Location:1956 → 2122
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2159 → 2256
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2678 → 2935
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    13. XM_036163113.1 → XP_036019006.1  neurobeachin isoform X3

      Conserved Domains (7) summary
      sd00039
      Location:2741 → 2795
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2288 → 2585
      Beach; Beige/BEACH domain
      pfam06469
      Location:1956 → 2122
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2159 → 2256
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2694 → 2951
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    14. XM_036163111.1 → XP_036019004.1  neurobeachin isoform X1

      Conserved Domains (7) summary
      sd00039
      Location:2746 → 2800
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2288 → 2585
      Beach; Beige/BEACH domain
      pfam06469
      Location:1956 → 2122
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2159 → 2256
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2699 → 2956
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    15. XM_036163119.1 → XP_036019012.1  neurobeachin isoform X15

      Conserved Domains (6) summary
      sd00039
      Location:2255 → 2309
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1797 → 2094
      Beach; Beige/BEACH domain
      pfam06469
      Location:1465 → 1631
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:1668 → 1765
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:21 → 236
      DUF4704; Domain of unknown function (DUF4704)
      cl29593
      Location:2208 → 2465
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    16. XM_036163122.1 → XP_036019015.1  neurobeachin isoform X20

      Conserved Domains (4) summary
      sd00039
      Location:588 → 642
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:151 → 427
      Beach; Beige/BEACH domain
      pfam14844
      Location:22 → 119
      PH_BEACH; PH domain associated with Beige/BEACH
      cl29593
      Location:541 → 798
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    17. XM_030252626.1 → XP_030108486.1  neurobeachin isoform X21

      Conserved Domains (4) summary
      sd00039
      Location:517 → 571
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:80 → 356
      Beach; Beige/BEACH domain
      cl17171
      Location:2 → 48
      PH-like; Pleckstrin homology-like domain
      cl29593
      Location:470 → 727
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    18. XM_036163121.1 → XP_036019014.1  neurobeachin isoform X17

      Conserved Domains (2) summary
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    19. XM_036163120.1 → XP_036019013.1  neurobeachin isoform X16

      Conserved Domains (2) summary
      pfam15787
      Location:467 → 727
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    20. XM_006501525.4 → XP_006501588.1  neurobeachin isoform X18

      Conserved Domains (2) summary
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    21. XM_006501526.5 → XP_006501589.1  neurobeachin isoform X19

      Conserved Domains (2) summary
      pfam15787
      Location:462 → 733
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:245 → 392
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RNA

    1. XR_001783693.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPN1.1 GenPept UniProtKB/Swiss-Prot:Q9EPN1

    Gene LinkOut

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