Liat1 ligand of ATE1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Liat1provided by MGI
Official Full Name: ligand of ATE1provided by MGI
Primary source: MGI:MGI:1921480
See related: Ensembl:ENSMUSG00000053783 AllianceGenome:MGI:1921480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700016K19Rik
Summary: Enables molecular condensate scaffold activity. Involved in membraneless organelle assembly and protein arginylation. Is active in nucleolus. Is expressed in several structures, including male reproductive gland or organ; metanephros; respiratory system; and thyroid gland. Orthologous to human LIAT1 (ligand of ATE1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 106.9) and lung adult (RPKM 5.3) See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75890738..75894395)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75999912..76003569)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6.
Title: The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6.
Liat1 interacts with Ate1 but does not appear to be its arginylation substrate. It has a higher affinity for the isoforms Ate1 1A7A and 1B7A. It stimulated N-terminal arginylation of a model substrate by Ate1. Sequelogs of other species are compared.
Title: Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular condensate scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in membraneless organelle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein arginylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein LIAT1

Names: ligand of ATE1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.