Nhlrc3 NHL repeat containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nhlrc3provided by MGI
Official Full Name: NHL repeat containing 3provided by MGI
Primary source: MGI:MGI:2444520
See related: Ensembl:ENSMUSG00000042997 AllianceGenome:MGI:2444520
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4083; 4833441N19; 8030451K01Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Is expressed in embryo. Orthologous to human NHLRC3 (NHL repeat containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in placenta adult (RPKM 7.8), colon adult (RPKM 5.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 25.15 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (53359417..53370679, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (53451996..53463258, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

BE134316 (e-PCR)
- UniSTS:207485

NoName (e-PCR)
- UniSTS:488359

NoName (e-PCR)
- UniSTS:234676

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NHL repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172501.2 → NP_766089.1 NHL repeat-containing protein 3 precursor

Status: PROVISIONAL

Source sequence(s)

AK033167

Consensus CDS

CCDS17345.1

UniProtKB/Swiss-Prot

Q8CCH2, Q8CDW5

Related

ENSMUSP00000055295.8, ENSMUST00000056749.14

Conserved Domains (3) summary

COG3391
Location:66 → 308

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd05819
Location:107 → 153

NHL; NHL repeat [structural motif]

cl18310
Location:66 → 336

NHL; NHL repeat unit of beta-propeller proteins