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    Akap11 A-kinase anchoring protein 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498549, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Akap11provided by RGD
    Official Full Name
    A-kinase anchoring protein 11provided by RGD
    Primary source
    RGD:2079
    See related
    EnsemblRapid:ENSRNOG00000009987 AllianceGenome:RGD:2079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akap
    Summary
    Enables kinase regulator activity; protein kinase A binding activity; and protein phosphatase 1 binding activity. Involved in positive regulation of establishment of endothelial barrier and positive regulation of protein phosphorylation. Located in peroxisome. Part of protein-containing complex. Orthologous to human AKAP11 (A-kinase anchoring protein 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 410.4), Kidney (RPKM 202.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akap11 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (60320839..60365480, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (53911635..53956138, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (60722138..60766673, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 11 Neighboring gene uncharacterized LOC102549816 Neighboring gene uncharacterized LOC120097049 Neighboring gene diacylglycerol kinase, eta Neighboring gene uncharacterized LOC108353040

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis. Garnis C, et al. Int J Cancer, 2005 Sep 20. PMID 15849745
    2. AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts. Okutsu R, et al. Kidney Int, 2008 Dec. PMID 19008911
    3. GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. Yang L, et al. J Pharmacol Sci, 2008 Apr. PMID 18385542
    4. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. Lester LB, et al. J Biol Chem, 1996 Apr 19. PMID 8621616
    5. PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. Radeva MY, et al. PLoS One, 2014. PMID 25188285, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest that GABA(C)-receptor rho subunit stimulation activates PKA via A-kinase anchoring protein 220 (AKAP 220).
      Title: GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A catalytic subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase A regulatory subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase A regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in renal water homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within renal water homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A-kinase anchor protein 11
    Names
    A kinase (PRKA) anchor protein 11
    A-kinase anchor protein 220 kDa
    A-kinase anchoring protein 220, AKAP 220
    AKAP 220
    AKAP-11
    PRKA11
    protein kinase A-anchoring protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394793.1 → NP_001381722.1  A-kinase anchor protein 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HTX6, D3ZS99
      Conserved Domains (1) summary
      cl14906
      Location:1778 → 1879
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      60320839..60365480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274564.1 → XP_063130634.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/TrEMBL
      A6HTX6, D3ZS99

    2. XM_063274565.1 → XP_063130635.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/TrEMBL
      A6HTX6, D3ZS99

    3. XM_039093595.2 → XP_038949523.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/TrEMBL
      A6HTX6, D3ZS99
      Related
      ENSRNOP00000101853.1, ENSRNOT00000150759.1
      Conserved Domains (1) summary
      cl14906
      Location:1779 → 1880
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    4. XM_017599779.2 → XP_017455268.1  A-kinase anchor protein 11 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZI9
      Related
      ENSRNOP00000101392.1, ENSRNOT00000169244.1

    5. XM_063274563.1 → XP_063130633.1  A-kinase anchor protein 11 isoform X2

      UniProtKB/TrEMBL
      A6HTX6, D3ZS99

    6. XM_063274562.1 → XP_063130632.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/TrEMBL
      A6HTX6, D3ZS99

    7. XM_039093596.2 → XP_038949524.1  A-kinase anchor protein 11 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLR8

    8. XM_017599780.3 → XP_017455269.1  A-kinase anchor protein 11 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GLR8
      Related
      ENSRNOP00000103392.1, ENSRNOT00000171831.1

    9. XM_063274566.1 → XP_063130636.1  A-kinase anchor protein 11 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GLR8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_012773.2: Suppressed sequence

      Description
      NM_012773.2: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62924.1 GenPept UniProtKB/Swiss-Prot:Q62924

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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