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    Tpm3 tropomyosin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117557, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tpm3provided by RGD
    Official Full Name
    tropomyosin 3provided by RGD
    Primary source
    RGD:621546
    See related
    EnsemblRapid:ENSRNOG00000017441 AllianceGenome:RGD:621546
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tpm5; TM30nm
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in brush border. Human ortholog(s) of this gene implicated in congenital myopathy 4A and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 928.6), Spleen (RPKM 397.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tpm3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177812534..177842661)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175517198..175545014)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189423534..189451340)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NS5A transactivated protein 4 Neighboring gene cilia and flagella associated protein 141 Neighboring gene microRNA 190b Neighboring gene transfer RNA proline (anticodon AGG) 20 Neighboring gene nucleoporin 210-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tropomyosin alpha-3 chain
    Names
    gamma-tropomyosin
    nonmuscle tropomyosin 5
    tropomyosin 3, gamma
    tropomyosin non-muscle
    tropomyosin-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301285.1NP_001288214.1  tropomyosin alpha-3 chain isoform Tpm3.12st

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (Tpm3.12, also known as variant 3) encodes the longest isoform (Tpm3.12st, also known as isoform 3). The encoded protein is a fast skeletal muscle isoform.
      Source sequence(s)
      FQ215580
      Related
      ENSRNOP00000035561.5, ENSRNOT00000029076.7
      Conserved Domains (3) summary
      pfam00261
      Location:49283
      Tropomyosin; Tropomyosin
      pfam07851
      Location:181275
      TMPIT; TMPIT-like protein
      pfam16526
      Location:1473
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    2. NM_001301286.1NP_001288215.1  tropomyosin alpha-3 chain isoform Tpm3.3cy

      See identical proteins and their annotated locations for NP_001288215.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (Tpm3.3, also known as variant 4) differs in the 5' UTR and coding sequence compared to variant Tpm3.12. The resulting isoform (Tpm3.3cy, also known as isoform 4) has a shorter and distinct N-terminus compared to isoform Tpm3.12st.
      Source sequence(s)
      FQ215580, L24776
      UniProtKB/TrEMBL
      A6J6K0
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    3. NM_057208.2NP_476556.2  tropomyosin alpha-3 chain isoform Tpm3.4cy

      See identical proteins and their annotated locations for NP_476556.2

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (Tpm3.4, also known as variant 1) differs in both UTR's and the coding region but maintains the reading frame, compared to variant Tpm3.12. This results in an isoform (Tpm3.4cy, also known as isoform 1) that is shorter at both the N- and C-termini, compared to isoform Tpm3.12st.
      Source sequence(s)
      L24777
      UniProtKB/TrEMBL
      A6J6J8
      Related
      ENSRNOP00000109938.1, ENSRNOT00000166501.1
      Conserved Domains (1) summary
      pfam00261
      Location:12245
      Tropomyosin
    4. NM_173111.2NP_775134.2  tropomyosin alpha-3 chain isoform Tpm3.1cy

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (Tpm3.1, also known as variant 2) differs in both UTR's and the coding region but maintains the reading frame, compared to variant Tpm3.12. This results in an isoform (Tpm3.1cy, also known as isoform 2) that is shorter at both the N- and C-termini, compared to isoform Tpm3.12st.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q63599, Q63600, Q63601, Q63610
      UniProtKB/TrEMBL
      A6J6J6
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177812534..177842661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232569.5XP_006232631.1  tropomyosin alpha-3 chain isoform X5

      See identical proteins and their annotated locations for XP_006232631.1

      Conserved Domains (2) summary
      pfam00261
      Location:49283
      Tropomyosin
      pfam16526
      Location:1473
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    2. XM_006232568.5XP_006232630.1  tropomyosin alpha-3 chain isoform X3

      See identical proteins and their annotated locations for XP_006232630.1

      UniProtKB/TrEMBL
      A0A8I6A144, A6J6J4
      Conserved Domains (1) summary
      pfam00261
      Location:49283
      Tropomyosin
    3. XM_006232573.5XP_006232635.1  tropomyosin alpha-3 chain isoform X7

      See identical proteins and their annotated locations for XP_006232635.1

      UniProtKB/TrEMBL
      A0A140TAF0, A6J6J5
      Related
      ENSRNOP00000094091.1, ENSRNOT00000101614.2
      Conserved Domains (2) summary
      pfam00261
      Location:49283
      Tropomyosin
      pfam16526
      Location:1473
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    4. XM_006232572.5XP_006232634.1  tropomyosin alpha-3 chain isoform X6

      See identical proteins and their annotated locations for XP_006232634.1

      Conserved Domains (1) summary
      pfam00261
      Location:49283
      Tropomyosin
    5. XM_006232576.5XP_006232638.1  tropomyosin alpha-3 chain isoform X8

      Conserved Domains (2) summary
      pfam00261
      Location:49282
      Tropomyosin
      pfam16526
      Location:1473
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    6. XM_006232577.5XP_006232639.1  tropomyosin alpha-3 chain isoform X9

      See identical proteins and their annotated locations for XP_006232639.1

      Conserved Domains (1) summary
      pfam00261
      Location:49282
      Tropomyosin
    7. XM_063281193.1XP_063137263.1  tropomyosin alpha-3 chain isoform X1

    8. XM_006232570.5XP_006232632.1  tropomyosin alpha-3 chain isoform X4

      See identical proteins and their annotated locations for XP_006232632.1

      Conserved Domains (2) summary
      pfam00261
      Location:49283
      Tropomyosin
      pfam16526
      Location:1473
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    9. XM_063281194.1XP_063137264.1  tropomyosin alpha-3 chain isoform X2

    10. XM_063281196.1XP_063137266.1  tropomyosin alpha-3 chain isoform X11

    11. XM_063281197.1XP_063137267.1  tropomyosin alpha-3 chain isoform X15

      UniProtKB/TrEMBL
      A6J6K0
      Related
      ENSRNOP00000079275.2, ENSRNOT00000112248.2
    12. XM_063281195.1XP_063137265.1  tropomyosin alpha-3 chain isoform X10

    13. XM_006232584.5XP_006232646.1  tropomyosin alpha-3 chain isoform X16

      UniProtKB/TrEMBL
      A0A8L2QDD9
      Related
      ENSRNOP00000023605.4, ENSRNOT00000023605.9
      Conserved Domains (1) summary
      pfam00261
      Location:12245
      Tropomyosin
    14. XM_006232581.5XP_006232643.1  tropomyosin alpha-3 chain isoform X14

      Related
      ENSRNOP00000097306.2, ENSRNOT00000101991.2
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    15. XM_039101596.2XP_038957524.1  tropomyosin alpha-3 chain isoform X13

      UniProtKB/TrEMBL
      A0A8L2QDD2
      Related
      ENSRNOP00000023567.6, ENSRNOT00000023567.10
    16. XM_039101595.2XP_038957523.1  tropomyosin alpha-3 chain isoform X12

      UniProtKB/TrEMBL
      A0A8L2QDD2
    17. XM_063281200.1XP_063137270.1  tropomyosin alpha-3 chain isoform X20

    18. XM_063281198.1XP_063137268.1  tropomyosin alpha-3 chain isoform X17

    19. XM_063281199.1XP_063137269.1  tropomyosin alpha-3 chain isoform X19

    20. XM_039101597.2XP_038957525.1  tropomyosin alpha-3 chain isoform X18

      UniProtKB/TrEMBL
      A0A8I6G322
      Related
      ENSRNOP00000085183.2, ENSRNOT00000114156.2
      Conserved Domains (1) summary
      pfam00261
      Location:20222
      Tropomyosin