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    Per3 period circadian regulator 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 78962, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Per3provided by RGD
    Official Full Name
    period circadian regulator 3provided by RGD
    Primary source
    RGD:621581
    See related
    EnsemblRapid:ENSRNOG00000018413 AllianceGenome:RGD:621581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rper3; period3
    Summary
    This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in Heart (RPKM 92.3), Lung (RPKM 86.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Per3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166740914..166778243, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161460228..161495404, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (168088126..168123482, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556501 Neighboring gene uncharacterized LOC134487044 Neighboring gene urotensin 2 Neighboring gene calmodulin binding transcription activator 1 Neighboring gene vesicle-associated membrane protein 3 Neighboring gene uncharacterized LOC134487045

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Kita Y, et al. Pharmacogenetics, 2002 Jan. PMID 11773865
    2. Sleep ability mediates individual differences in the vulnerability to sleep loss: evidence from a PER3 polymorphism. Maire M, et al. Cortex, 2014 Mar. PMID 24439663
    3. Altered sleep and behavioral activity phenotypes in PER3-deficient mice. Hasan S, et al. Am J Physiol Regul Integr Comp Physiol, 2011 Dec. PMID 21957163
    4. PERIOD3, circadian phenotypes, and sleep homeostasis. Dijk DJ, et al. Sleep Med Rev, 2010 Jun. PMID 19716732
    5. PER3 polymorphism predicts sleep structure and waking performance. Viola AU, et al. Curr Biol, 2007 Apr 3. PMID 17346965

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of circadian sleep/wake cycle, sleep IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of circadian sleep/wake cycle, sleep ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of circadian sleep/wake cycle, sleep ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    period circadian protein homolog 3
    Names
    circadian clock protein PERIOD 3
    period circadian clock 3
    period homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023978.2 → NP_076468.2  period circadian protein homolog 3

      See identical proteins and their annotated locations for NP_076468.2

      Status: VALIDATED

      Source sequence(s)
      AB092512, JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IUE8, G3V8D9
      Related
      ENSRNOP00000024932.6, ENSRNOT00000024932.7
      Conserved Domains (3) summary
      cd00130
      Location:281 → 373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:281 → 369
      PAS_3; PAS fold
      pfam12114
      Location:907 → 1108
      Period_C; Period protein 2/3C-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      166740914..166778243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239505.5 → XP_006239567.1  period circadian protein homolog 3 isoform X2

      UniProtKB/TrEMBL
      G3V8D9
      Conserved Domains (3) summary
      cd00130
      Location:281 → 373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:281 → 369
      PAS_3; PAS fold
      pfam12114
      Location:906 → 1107
      Period_C; Period protein 2/3C-terminal region

    2. XM_006239504.5 → XP_006239566.1  period circadian protein homolog 3 isoform X1

      UniProtKB/TrEMBL
      G3V8D9
      Conserved Domains (3) summary
      cd00130
      Location:281 → 373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:281 → 369
      PAS_3; PAS fold
      pfam12114
      Location:907 → 1108
      Period_C; Period protein 2/3C-terminal region

    3. XM_063288459.1 → XP_063144529.1  period circadian protein homolog 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CJE2.1 GenPept UniProtKB/Swiss-Prot:Q8CJE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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