Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkar1aprovided by RGD
Official Full Name: protein kinase cAMP-dependent type I regulatory subunit alphaprovided by RGD
Primary source: RGD:3391
See related: EnsemblRapid:ENSRNOG00000049876 AllianceGenome:RGD:3391
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RIIA
Summary: Enables cAMP binding activity and cAMP-dependent protein kinase regulator activity. Involved in female meiotic nuclear division; negative regulation of meiotic nuclear division; and regulation of protein kinase activity. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease 1. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: On NCBI's build 4.2, GeneID 25725 (Prkar1a) was annotated incorrectly on chromosome X of the reference assembly but annotated correctly on chromosome 10 of the alternate Celera assembly. The chromosome X location appears to be a Prkar1a pseudogene now represented by GeneID 100510791 and the Reference Sequence NG_027837. [17 Jun 2014]
Expression: Biased expression in Heart (RPKM 1515.5), Brain (RPKM 1074.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (95120537..95139028)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (94621042..94639534)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (97940705..97959199)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role for PKA signaling in both short- and long-term regulation of AQP2, characterizing a novel mouse model of diabetes insipidus
Title: Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype.
hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 induces cardiomyocyte apoptosis.
Title: Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis.
a key role for AKAP-targeted PKA in control of heart rate and contractile function
Title: Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function.
EPAC & PKA modulate both distinct & common exocytic steps to potentiate insulin exocytosis. EPAC mobilizes SGs to fuse at the PM. PKA & EPAC synergistically modulate SG-SG fusions underlying compound & sequential exocytoses.
Title: Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells.
dystrobrevin is a scaffold protein that may play a role in different cellular processes involving PKA signaling
Title: Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins.
protein kinase A is controlled by Fos-related antigen 2 and has a role in inducing CCAAT/enhancer-binding protein beta expression in osteoblasts
Title: Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts.
the PKA RIalpha subunit dynamic C helix mediates isoform-specific domain reorganization upon C subunit binding
Title: The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.
cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes
Title: cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes.
PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching
Title: PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
GABA B receptor-mediated inhibitory action on GABA release was mediated via decreases in protein kinase A activity.
Title: GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BM386718 (e-PCR)
- UniSTS:261517

RH131422 (e-PCR)
- UniSTS:214705

RH94506 (e-PCR)
- UniSTS:119754

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase regulator activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A catalytic subunit binding	IC Inferred by Curator more info	PubMed
enables protein kinase A catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucagon stimulus	ISO Inferred from Sequence Orthology more info
involved_in female meiotic nuclear division	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP/PKA signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of meiotic nuclear division	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sarcomere organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of cAMP-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
part_of nucleotide-activated protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sperm head-tail coupling apparatus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cAMP-dependent protein kinase type I-alpha regulatory subunit

Names: protein kinase cAMP-dependent type 1 regulatory subunit alpha; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha

NP_037313.1

EC 2.7.11.1

XP_008766533.2

EC 2.7.11.1

XP_038941226.1

EC 2.7.11.1

XP_063124556.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013181.2 → NP_037313.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

See identical proteins and their annotated locations for NP_037313.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P09456

UniProtKB/TrEMBL

A0A8I5ZQ48, A6HKB8

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

95120537..95139028

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768311.3 → XP_008766533.2 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

UniProtKB/TrEMBL

A0A8I6A621

Related

ENSRNOP00000088358.1, ENSRNOT00000119272.2
XM_063268486.1 → XP_063124556.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X2

Related

ENSRNOP00000095855.2, ENSRNOT00000094613.2
XM_039085298.2 → XP_038941226.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X3

UniProtKB/Swiss-Prot

P09456

UniProtKB/TrEMBL

A0A8I5ZQ48, A6HKB8

Related

ENSRNOP00000067771.3, ENSRNOT00000071153.3

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...