Wrap73 WD repeat containing, antisense to TP73 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wrap73provided by RGD
Official Full Name: WD repeat containing, antisense to TP73provided by RGD
Primary source: RGD:1359137
See related: EnsemblRapid:ENSRNOG00000014805 AllianceGenome:RGD:1359137
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wdr8
Summary: Predicted to be involved in mitotic spindle assembly and positive regulation of non-motile cilium assembly. Predicted to be located in centrosome and ciliary basal body. Predicted to be part of MWP complex. Predicted to be active in microtubule organizing center. Orthologous to human WRAP73 (WD repeat containing, antisense to TP73). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 64.1), Brain (RPKM 55.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (169988538..170004071)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (164706112..164721645)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (171441471..171455795)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-motile cilium assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MWP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein WRAP73

Names: WD repeat domain 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014262.1 → NP_001014284.1 WD repeat-containing protein WRAP73

See identical proteins and their annotated locations for NP_001014284.1

Status: PROVISIONAL

Source sequence(s)

BC082062

UniProtKB/TrEMBL

A0A8I5YCM5, F1LS25, Q641Y4

Related

ENSRNOP00000019873.7, ENSRNOT00000019873.8

Conserved Domains (3) summary

COG2319
Location:13 → 413

WD40; WD40 repeat [General function prediction only]

sd00039
Location:14 → 47

7WD40; WD40 repeat [structural motif]

cl02567
Location:89 → 401

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...