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    Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311039, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Galnt13provided by RGD
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 13provided by RGD
    Primary source
    RGD:735044
    See related
    EnsemblRapid:ENSRNOG00000005335 AllianceGenome:RGD:735044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    T13
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 104.1), Adrenal (RPKM 97.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galnt13 in Genome Data Viewer
    Location:
    3q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (59312628..59969633)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (38903695..39560683)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (39967056..40625144)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene dyskerin pseudouridine synthase 1, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene mitochondrial ribosomal protein S21, pseudogene 2 Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 23 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108350374

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. Zhang Y, et al. J Biol Chem, 2003 Jan 3. PMID 12407114
    2. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Raman J, et al. Glycobiology, 2012 Jun. PMID 22186971, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via threonine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 13
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
    galNAc-T13
    polypeptide GalNAc transferase 13
    pp-GaNTase 13
    protein-UDP acetylgalactosaminyltransferase 13
    NP_954537.1
    XP_017447163.1
    XP_017447164.1
    XP_017447165.1
    XP_038960744.1
    XP_038960745.1
    XP_038960746.1
    XP_063139678.1
    XP_063139679.1
    XP_063139680.1
    XP_063139681.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431574.1 → NP_001418503.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6UE39
      UniProtKB/TrEMBL
      A0A8L2QKT0, A6JF40

    2. NM_001431575.1 → NP_001418504.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6GB66, A0A8L2QKT0

    3. NM_001431576.1 → NP_001418505.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_001431577.1 → NP_001418506.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_199106.3 → NP_954537.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform a

      See identical proteins and their annotated locations for NP_954537.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6UE39
      UniProtKB/TrEMBL
      A0A8L2QKT0, A6JF40
      Related
      ENSRNOP00000042772.6, ENSRNOT00000048804.6
      Conserved Domains (3) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:431 → 549
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:431 → 547
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      59312628..59969633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283608.1 → XP_063139678.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GB66, A0A8L2QKT0

    2. XM_017591676.3 → XP_017447165.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

      Conserved Domains (3) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:431 → 549
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:431 → 547
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. XM_017591675.3 → XP_017447164.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QKT0

    4. XM_017591674.3 → XP_017447163.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 548
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    5. XM_039104816.2 → XP_038960744.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GB66, A0A8L2QKT0
      Related
      ENSRNOP00000084878.1, ENSRNOT00000111296.2
      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 548
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    6. XM_039104817.2 → XP_038960745.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GB66, A0A8L2QKT0
      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 548
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    7. XM_063283609.1 → XP_063139679.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

    8. XM_063283610.1 → XP_063139680.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X4

      UniProtKB/TrEMBL
      A0A8L2QKT0
      Related
      ENSRNOP00000100640.1, ENSRNOT00000170230.1

    9. XM_039104818.2 → XP_038960746.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X5

      Conserved Domains (1) summary
      cd02510
      Location:118 → 385
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

    10. XM_063283611.1 → XP_063139681.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UE39.1 GenPept UniProtKB/Swiss-Prot:Q6UE39

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