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    Dhrs4 dehydrogenase/reductase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhrs4provided by RGD
    Official Full Name
    dehydrogenase/reductase 4provided by RGD
    Primary source
    RGD:708482
    See related
    EnsemblRapid:ENSRNOG00000018239 AllianceGenome:RGD:708482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PSCD
    Summary
    Predicted to enable several functions, including 3-keto sterol reductase activity; alcohol dehydrogenase (NADP+) activity; and retinal dehydrogenase activity. Predicted to be involved in several processes, including positive regulation of reactive oxygen species metabolic process; retinal metabolic process; and steroid metabolic process. Located in peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 361.9), Liver (RPKM 304.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhrs4 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32924482..32948103)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28966544..28978135)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34155043..34167073)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482121 Neighboring gene uncharacterized LOC102551831 Neighboring gene ribosomal protein S17, pseudogene 8 Neighboring gene uncharacterized LOC102552093 Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel isoform of DHRS4 protein with a nuclear localization signal. Su Z, et al. Gene, 2012 Feb 25. PMID 22227495
    2. Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity. Matsunaga T, et al. Arch Biochem Biophys, 2008 Sep 15. PMID 18571493
    3. Molecular basis for peroxisomal localization of tetrameric carbonyl reductase. Tanaka N, et al. Structure, 2008 Mar. PMID 18334214
    4. Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate. Lei Z, et al. Biochemistry, 2003 Apr 15. PMID 12680773
    5. Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). Endo S, et al. Arch Biochem Biophys, 2009 Jan 15. PMID 19056333

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-keto sterol reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alcohol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ketone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 4
    Names
    CR
    DCR-AKL
    NADP-retinol dehydrogenase
    NADPH-dependent carbonyl reductase
    NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
    NADPH-dependent retinol dehydrogenase/reductase
    NDRD
    PHCR
    carbonyl reductase
    dehydrogenase/reductase (SDR family) member 4
    peroxisomal short-chain alcohol dehydrogenase
    short chain dehydrogenase/reductase family 25C member 2
    NP_695227.2
    XP_038948968.1
    XP_063130103.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433420.1 → NP_001420349.1  dehydrogenase/reductase SDR family member 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZUW8

    2. NM_001433421.1 → NP_001420350.1  dehydrogenase/reductase SDR family member 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q6IRD4, Q8VID1
      UniProtKB/TrEMBL
      A0A8I5ZUW8

    3. NM_153315.3 → NP_695227.2  dehydrogenase/reductase SDR family member 4 isoform 1

      See identical proteins and their annotated locations for NP_695227.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q6IRD4, Q8VID1
      UniProtKB/TrEMBL
      A0A8I5ZUW8
      Related
      ENSRNOP00000024782.3, ENSRNOT00000024782.6
      Conserved Domains (1) summary
      cd08936
      Location:24 → 279
      CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR

    RNA

    1. NR_197357.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32924482..32948103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274033.1 → XP_063130103.1  dehydrogenase/reductase SDR family member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6IRD4, Q8VID1
      UniProtKB/TrEMBL
      A0A8I5ZUW8

    2. XM_039093040.2 → XP_038948968.1  dehydrogenase/reductase SDR family member 4 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:24 → 225
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VID1.2 GenPept UniProtKB/Swiss-Prot:Q8VID1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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