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    Arsg arylsulfatase G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303631, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arsgprovided by RGD
    Official Full Name
    arylsulfatase Gprovided by RGD
    Primary source
    RGD:1306571
    See related
    EnsemblRapid:ENSRNOG00000003931 AllianceGenome:RGD:1306571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306571
    Summary
    Predicted to enable N-sulfoglucosamine-3-sulfatase activity and arylsulfatase activity. Predicted to be involved in sulfur compound metabolic process. Predicted to act upstream of or within several processes, including lysosome organization; neuron apoptotic process; and retina development in camera-type eye. Predicted to be located in endoplasmic reticulum; extracellular space; and lysosome. Human ortholog(s) of this gene implicated in Usher syndrome. Orthologous to human ARSG (arylsulfatase G). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 49.0), Spleen (RPKM 37.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arsg in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (94912094..95063021)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94412261..94551224)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97722550..97859975)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 13 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene 5E5 antigen-like Neighboring gene solute carrier family 16, member 6 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene uncharacterized LOC100912202 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene uncharacterized LOC134480894 Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Arylsulfatase G, a novel lysosomal sulfatase. Frese MA, et al. J Biol Chem, 2008 Apr 25. PMID 18283100
    2. Molecular and biochemical characterisation of a novel sulphatase gene: Arylsulfatase G (ARSG). Ferrante P, et al. Eur J Hum Genet, 2002 Dec. PMID 12461688
    3. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
    4. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-sulfoglucosamine-3-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylsulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables arylsulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylsulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylsulfatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arylsulfatase G
    Names
    ASG
    N-sulfoglucosamine-3-sulfatase
    NP_001041342.1
    XP_006247664.1
    XP_006247666.1
    XP_006247668.1
    XP_006247669.1
    XP_006247670.1
    XP_008766591.1
    XP_038942102.1
    XP_038942103.1
    XP_038942104.1
    XP_038942105.1
    XP_063125292.1
    XP_063125293.1
    XP_063125294.1
    XP_063125295.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047877.2 → NP_001041342.1  arylsulfatase G precursor

      See identical proteins and their annotated locations for NP_001041342.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      94912094..95063021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269225.1 → XP_063125295.1  arylsulfatase G isoform X2

    2. XM_039086177.2 → XP_038942105.1  arylsulfatase G isoform X4

      Conserved Domains (1) summary
      cl23718
      Location:35 → 328
      ALP_like; alkaline phosphatases and sulfatases

    3. XM_039086176.2 → XP_038942104.1  arylsulfatase G isoform X3

      Conserved Domains (1) summary
      cl23718
      Location:35 → 331
      ALP_like; alkaline phosphatases and sulfatases

    4. XM_008768369.3 → XP_008766591.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_008766591.1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    5. XM_039086174.2 → XP_038942102.1  arylsulfatase G isoform X1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Related
      ENSRNOP00000086727.1, ENSRNOT00000113597.2
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    6. XM_039086175.2 → XP_038942103.1  arylsulfatase G isoform X1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    7. XM_006247602.5 → XP_006247664.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_006247664.1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    8. XM_006247608.5 → XP_006247670.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_006247670.1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    9. XM_063269222.1 → XP_063125292.1  arylsulfatase G isoform X1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4

    10. XM_006247604.5 → XP_006247666.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_006247666.1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    11. XM_006247606.5 → XP_006247668.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_006247668.1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    12. XM_063269223.1 → XP_063125293.1  arylsulfatase G isoform X1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4

    13. XM_063269224.1 → XP_063125294.1  arylsulfatase G isoform X1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4

    14. XM_006247607.5 → XP_006247669.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_006247669.1

      UniProtKB/Swiss-Prot
      Q32KJ9
      UniProtKB/TrEMBL
      A6HKB4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    RNA

    1. XR_005489859.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32KJ9.1 GenPept UniProtKB/Swiss-Prot:Q32KJ9

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