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    Ccdc3 coiled-coil domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498795, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ccdc3provided by RGD
    Official Full Name
    coiled-coil domain containing 3provided by RGD
    Primary source
    RGD:1559473
    See related
    EnsemblRapid:ENSRNOG00000017933 AllianceGenome:RGD:1559473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559473
    Summary
    Predicted to be involved in negative regulation of metabolic process; negative regulation of tumor necrosis factor-mediated signaling pathway; and signal transduction. Predicted to act upstream of or within negative regulation of lipid biosynthetic process; positive regulation of fat cell differentiation; and positive regulation of lipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular region. Orthologous to human CCDC3 (coiled-coil domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 42.7), Adrenal (RPKM 38.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc3 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (77941148..78044820, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (73031891..73135173, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (76991722..77093515, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551092 Neighboring gene calcium/calmodulin-dependent protein kinase ID Neighboring gene uncharacterized LOC108348589 Neighboring gene uncharacterized LOC108348590 Neighboring gene uncharacterized LOC134482742 Neighboring gene optineurin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fat/vessel-derived secretory protein (Favine)/CCDC3 is involved in lipid accumulation. Kobayashi S, et al. J Biol Chem, 2015 Mar 20. PMID 25605713, Free PMC Article
    2. Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-α/nuclear factor κB-induced endothelial inflammation. Azad AK, et al. Cell Signal, 2014 Dec. PMID 25193116
    3. Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism. Liao W, et al. Sci Rep, 2017 Aug 21. PMID 28827783, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain containing 3; coiled-coil domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432312.1 → NP_001419241.1  coiled-coil domain containing 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6JLY8, D3ZAR0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      77941148..78044820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_574081.9 → XP_574081.4  coiled-coil domain-containing protein 3

      Related
      ENSRNOP00000024110.3, ENSRNOT00000024110.6
      Conserved Domains (1) summary
      pfam10211
      Location:184 → 249
      Ax_dynein_light; Axonemal dynein light chain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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