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    Pknox2 PBX/knotted 1 homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680549, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pknox2provided by RGD
    Official Full Name
    PBX/knotted 1 homeobox 2provided by RGD
    Primary source
    RGD:1590611
    See related
    EnsemblRapid:ENSRNOG00000028856 AllianceGenome:RGD:1590611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; actin filament binding activity; and actin monomer binding activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytoskeleton; intercellular bridge; and nucleoplasm. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PKNOX2 (PBX/knotted 1 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 66.8), Brain (RPKM 46.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pknox2 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (44789464..45051933, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36600633..36863131, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39361698..39551700, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene 60S ribosomal protein L14 pseudogene Neighboring gene uncharacterized LOC120094114 Neighboring gene uncharacterized LOC108351675 Neighboring gene transmembrane protein 218 Neighboring gene solute carrier family 37 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export. Haller K, et al. J Biol Chem, 2004 Nov 19. PMID 15339927
    2. Prep2: cloning and expression of a new prep family member. Haller K, et al. Dev Dyn, 2002 Nov. PMID 12412021
    3. An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. Chen G, et al. Addict Biol, 2017 Nov. PMID 27151647
    4. Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Ferretti E, et al. Mol Cell Biol, 2006 Aug. PMID 16847320, Free PMC Article
    5. Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Zhang X, et al. Dev Biol, 2006 Dec 15. PMID 17049510

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein PKNOX2
    Names
    homeobox protein Meis2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271278.1 → NP_001258207.1  homeobox protein PKNOX2 isoform 1

      See identical proteins and their annotated locations for NP_001258207.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Related
      ENSRNOP00000070748.2, ENSRNOT00000091894.3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    2. NM_001271279.1 → NP_001258208.1  homeobox protein PKNOX2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the 5' UTR and an additional exon in the 5' coding region, which results in a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A096MJK1
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      44789464..45051933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082146.2 → XP_038938074.1  homeobox protein PKNOX2 isoform X3

      Conserved Domains (3) summary
      pfam05920
      Location:194 → 229
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    2. XM_039082131.2 → XP_038938059.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    3. XM_039082142.2 → XP_038938070.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    4. XM_039082143.2 → XP_038938071.1  homeobox protein PKNOX2 isoform X2

      UniProtKB/TrEMBL
      A0A096MJK1
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    5. XM_063266117.1 → XP_063122187.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3

    6. XM_039082133.2 → XP_038938061.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    7. XM_039082132.2 → XP_038938060.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    8. XM_063266115.1 → XP_063122185.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3

    9. XM_063266119.1 → XP_063122189.1  homeobox protein PKNOX2 isoform X2

      UniProtKB/TrEMBL
      A0A096MJK1

    10. XM_039082135.2 → XP_038938063.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    11. XM_039082136.2 → XP_038938064.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    12. XM_039082137.2 → XP_038938065.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    13. XM_063266120.1 → XP_063122190.1  homeobox protein PKNOX2 isoform X2

      UniProtKB/TrEMBL
      A0A096MJK1

    14. XM_039082139.2 → XP_038938067.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    15. XM_039082138.2 → XP_038938066.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    16. XM_063266116.1 → XP_063122186.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3

    17. XM_039082134.2 → XP_038938062.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    18. XM_039082140.2 → XP_038938068.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ2, A6KRM3
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    19. XM_039082145.2 → XP_038938073.1  homeobox protein PKNOX2 isoform X2

      UniProtKB/TrEMBL
      A0A096MJK1
      Related
      ENSRNOP00000068159.2, ENSRNOT00000076158.4
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    20. XM_063266121.1 → XP_063122191.1  homeobox protein PKNOX2 isoform X4

    21. XM_039082148.1 → XP_038938076.1  homeobox protein PKNOX2 isoform X4

      Conserved Domains (3) summary
      pfam05920
      Location:173 → 212
      Homeobox_KN; Homeobox KN domain
      pfam10018
      Location:134 → 229
      Med4; Vitamin-D-receptor interacting Mediator subunit 4
      pfam16493
      Location:1 → 48
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    Nucleotide Protein Strain
    Heading Accession and Version

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