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    Tmco6 transmembrane and coiled-coil domains 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmco6provided by RGD
    Official Full Name
    transmembrane and coiled-coil domains 6provided by RGD
    Primary source
    RGD:1309263
    See related
    EnsemblRapid:ENSRNOG00000017718 AllianceGenome:RGD:1309263
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309263
    Summary
    Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Orthologous to human TMCO6 (transmembrane and coiled-coil domains 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 71.4), Thymus (RPKM 65.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmco6 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28623269..28629864)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28349248..28355843)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29579145..29585740)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17, pseudogene 9 Neighboring gene CD14 molecule Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106154.1 → NP_001099624.1  transmembrane and coiled-coil domain-containing protein 6

      See identical proteins and their annotated locations for NP_001099624.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473974
      UniProtKB/TrEMBL
      A6J328, B2RYM7, G3V979
      Related
      ENSRNOP00000038714.4, ENSRNOT00000038066.6
      Conserved Domains (3) summary
      COG5064
      Location:23 → 391
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:104 → 218
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:104 → 135
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      28623269..28629864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277214.1 → XP_063133284.1  transmembrane and coiled-coil domain-containing protein 6 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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