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    Atp6v1a ATPase H+ transporting V1 subunit A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685232, updated on 3-Dec-2024

    Summary

    Official Symbol
    Atp6v1aprovided by RGD
    Official Full Name
    ATPase H+ transporting V1 subunit Aprovided by RGD
    Primary source
    RGD:1596464
    See related
    EnsemblRapid:ENSRNOG00000001992 AllianceGenome:RGD:1596464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp6v1a1
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular response to increased oxygen levels; intracellular iron ion homeostasis; and synaptic vesicle lumen acidification. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 766.9), Kidney (RPKM 593.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atp6v1a in Genome Data Viewer
    Location:
    11q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (70066800..70120603)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56561444..56614694)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61531386..61584634)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene upstream transcription factor family member 3 Neighboring gene uncharacterized LOC120095658 Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit Neighboring gene uncharacterized LOC134481070 Neighboring gene GRAM domain containing 1C Neighboring gene zinc finger DHHC-type palmitoyltransferase 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
     
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proton-transporting ATPase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to increased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle lumen acidification ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in extrinsic component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proton-transporting V-type ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proton-transporting V-type ATPase, V1 domain ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase catalytic subunit A
    Names
    ATPase, H+ transporting, lysosomal V1 subunit A
    NP_001101788.1
    XP_006248410.1
    XP_006248411.1
    XP_063126837.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108318.2NP_001101788.1  V-type proton ATPase catalytic subunit A

      See identical proteins and their annotated locations for NP_001101788.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A1W2Q641, A6IR15
      Related
      ENSRNOP00000106748.1, ENSRNOT00000139767.1
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      70066800..70120603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270767.1XP_063126837.1  V-type proton ATPase catalytic subunit A isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q641, A6IR15
    2. XM_006248348.5XP_006248410.1  V-type proton ATPase catalytic subunit A isoform X1

      See identical proteins and their annotated locations for XP_006248410.1

      UniProtKB/TrEMBL
      A0A1W2Q641, A6IR15
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    3. XM_006248349.5XP_006248411.1  V-type proton ATPase catalytic subunit A isoform X1

      See identical proteins and their annotated locations for XP_006248411.1

      UniProtKB/TrEMBL
      A0A1W2Q641, A6IR15
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit