Arfgef2 ARF guanine nucleotide exchange factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arfgef2provided by RGD
Official Full Name: ARF guanine nucleotide exchange factor 2provided by RGD
Primary source: RGD:631430
See related: EnsemblRapid:ENSRNOG00000007485 AllianceGenome:RGD:631430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Big2
Summary: Enables GABA receptor binding activity and myosin binding activity. Involved in exocytosis. Located in several cellular components, including axonemal microtubule; symmetric synapse; and trans-Golgi network. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ARF guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 205.5), Adrenal (RPKM 130.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (175966575..176052715)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (155547504..155633652)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (163570435..163656612)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

interaction with the GABA(A)receptor beta subunits may play a role in the exocytosis and trafficking of assembled GABA(A) receptors to the cell surface
Title: The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors.

Submit: New GeneRIF Correction

General gene information

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Markers

AU046990 (e-PCR)
- UniSTS:110949

d3mgh2 (e-PCR)
- UniSTS:121781

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endomembrane system organization	ISO Inferred from Sequence Orthology more info
involved_in endomembrane system organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in receptor recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axonemal microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in symmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: brefeldin A-inhibited guanine nucleotide-exchange protein 2

Names: ADP ribosylation factor guanine nucleotide exchange factor 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Brefeldin A-inhibited guanine nucleotide-exchange factor 2; brefeldin A-inhibited GEP 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430231.1 → NP_001417160.1 brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JXH9
NM_181083.3 → NP_851597.2 brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1

See identical proteins and their annotated locations for NP_851597.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q7TSU1

UniProtKB/TrEMBL

A6JXH9

Related

ENSRNOP00000010054.4, ENSRNOT00000010054.7

Conserved Domains (5) summary

PLN03076
Location:11 → 1718

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

pfam01369
Location:650 → 834

Sec7; Sec7 domain

pfam09324
Location:1174 → 1255

DUF1981; Domain of unknown function (DUF1981)

pfam12783
Location:377 → 531

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

pfam16213
Location:28 → 198

DCB; Dimerization and cyclophilin-binding domain of Mon2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

175966575..176052715

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235640.5 → XP_006235702.1 brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1

Related

ENSRNOP00000096461.1, ENSRNOT00000103177.2

Conserved Domains (5) summary

PLN03076
Location:11 → 1717

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

pfam01369
Location:649 → 833

Sec7; Sec7 domain

pfam09324
Location:1173 → 1254

DUF1981; Domain of unknown function (DUF1981)

pfam12783
Location:376 → 530

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

pfam16213
Location:28 → 198

DCB; Dimerization and cyclophilin-binding domain of Mon2
XM_063283411.1 → XP_063139481.1 brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2

UniProtKB/TrEMBL

A6JXH9