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    Nelfb negative elongation factor complex member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311796, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nelfbprovided by RGD
    Official Full Name
    negative elongation factor complex member Bprovided by RGD
    Primary source
    RGD:1307832
    See related
    EnsemblRapid:ENSRNOG00000009377 AllianceGenome:RGD:1307832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cobra1; RGD1307832
    Summary
    Predicted to be involved in several processes, including negative regulation of stem cell differentiation; negative regulation of transcription elongation by RNA polymerase II; and stem cell differentiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of NELF complex. Orthologous to human NELFB (negative elongation factor complex member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 120.6), Kidney (RPKM 116.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nelfb in Genome Data Viewer
    Location:
    3p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28409045..28425564, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8010883..8027403, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2414448..2431148, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L23-like Neighboring gene Notch-regulated ankyrin repeat protein Neighboring gene torsin family 4, member A Neighboring gene RNA, U6 small nuclear 136 Neighboring gene sperm-tail PG-rich repeat containing 3 Neighboring gene ciliary microtubule inner protein 2A Neighboring gene tubulin, beta 4B class IVb

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of NELF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NELF complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    negative elongation factor B
    Names
    cofactor of BRCA1
    negative elongation factor protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107817.3NP_001101287.3  negative elongation factor B

      Status: VALIDATED

      Source sequence(s)
      BC160853, JAXUCZ010000003
      UniProtKB/TrEMBL
      D4ACV0
      Related
      ENSRNOP00000012978.6, ENSRNOT00000012978.7
      Conserved Domains (1) summary
      pfam06209
      Location:158629
      COBRA1; Cofactor of BRCA1 (COBRA1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28409045..28425564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)