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    Hrh1 histamine receptor H 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24448, updated on 3-Dec-2024

    Summary

    Official Symbol
    Hrh1provided by RGD
    Official Full Name
    histamine receptor H 1provided by RGD
    Primary source
    RGD:2830
    See related
    EnsemblRapid:ENSRNOG00000007420 AllianceGenome:RGD:2830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hisr
    Summary
    Enables histamine binding activity. Involved in several processes, including negative regulation of steroid biosynthetic process; positive regulation of nitric oxide biosynthetic process; and positive regulation of vasoconstriction. Predicted to be located in cytosol. Predicted to be active in dendrite and plasma membrane. Orthologous to human HRH1 (histamine receptor H1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Genomic context

    See Hrh1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (149120511..149204267)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (147564963..147649353)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (146374596..146458148)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548867 Neighboring gene solute carrier family 6 member 1 Neighboring gene uncharacterized LOC120102366 Neighboring gene endogenous retrovirus group K member 10 Gag polyprotein-like Neighboring gene endogenous retrovirus group K member 21 Env polyprotein-like Neighboring gene uncharacterized LOC120102368 Neighboring gene autophagy related 7

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histamine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histamine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histamine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histamine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histamine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to histamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to histamine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to histamine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of steroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to gravity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histamine H1 receptor
    Names
    H1R
    HH1R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017018.2NP_058714.2  histamine H1 receptor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P31390
      UniProtKB/TrEMBL
      A6IBV0, G3V6X5
      Related
      ENSRNOP00000109554.1, ENSRNOT00000124731.1
      Conserved Domains (1) summary
      cd15050
      Location:29478
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      149120511..149204267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107019.2XP_038962947.1  histamine H1 receptor isoform X1

      UniProtKB/Swiss-Prot
      P31390
      UniProtKB/TrEMBL
      A6IBV0, G3V6X5
      Related
      ENSRNOP00000103271.1, ENSRNOT00000156547.1
      Conserved Domains (1) summary
      cd15050
      Location:29478
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors