U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dctn1 dynactin subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29167, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dctn1provided by RGD
    Official Full Name
    dynactin subunit 1provided by RGD
    Primary source
    RGD:62038
    See related
    EnsemblRapid:ENSRNOG00000010048 AllianceGenome:RGD:62038
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity; microtubule binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; plasma membrane bounded cell projection organization; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within melanosome transport. Part of cytoplasmic dynein complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 396.1), Heart (RPKM 195.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dctn1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117228722..117261528)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115671024..115703824)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (114876770..114896567)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350719 Neighboring gene rhotekin Neighboring gene similar to human chromosome 2 open reading frame 81 Neighboring gene WD repeat domain 54 Neighboring gene solute carrier family 4 member 5 Neighboring gene uncharacterized LOC134486596 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    NOT involved_in axonal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole-centriole cohesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole-centriole cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic microtubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of mitotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in melanosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within melanosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule anchoring at centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule anchoring at centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule anchoring at centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in motor behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in motor behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuromuscular process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in non-motile cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear membrane disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear membrane disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear membrane disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventral spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventral spinal cord development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    part_of centriolar subdistal appendage IEA
    Inferred from Electronic Annotation
    more info
     
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of microtubule associated complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule plus-end IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of retromer complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dynactin subunit 1
    Names
    150 kDa dynein-associated polypeptide
    DAP-150
    DP-150
    dynactin 1
    p150-glued

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024130.2NP_077044.2  dynactin subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P28023
      UniProtKB/TrEMBL
      A0A0G2K428, A6IAL4
      Related
      ENSRNOP00000080377.2, ENSRNOT00000110975.2
      Conserved Domains (5) summary
      TIGR02168
      Location:220540
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:9241037
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05109
      Location:101214
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:527805
      Dynactin; Dynein associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117228722..117261528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107183.2XP_038963111.1  dynactin subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZPT7
      Related
      ENSRNOP00000095934.2, ENSRNOT00000100284.2
      Conserved Domains (5) summary
      TIGR02168
      Location:203523
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:9071020
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05109
      Location:84197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:510788
      Dynactin; Dynein associated protein
    2. XM_039107184.2XP_038963112.1  dynactin subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZPT7
      Conserved Domains (5) summary
      TIGR02168
      Location:203523
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:9071020
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05109
      Location:84197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:510788
      Dynactin; Dynein associated protein
    3. XM_063285669.1XP_063141739.1  dynactin subunit 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6ASG8
    4. XM_039107185.2XP_038963113.1  dynactin subunit 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6A3U0
      Related
      ENSRNOP00000082429.1, ENSRNOT00000107740.2
      Conserved Domains (4) summary
      TIGR02168
      Location:200520
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:9041017
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:507785
      Dynactin; Dynein associated protein
    5. XM_063285663.1XP_063141733.1  dynactin subunit 1 isoform X1

      UniProtKB/Swiss-Prot
      P28023
      UniProtKB/TrEMBL
      A0A8I6A3U0, A6IAL5
    6. XM_063285664.1XP_063141734.1  dynactin subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ASG8
      Related
      ENSRNOP00000072880.3, ENSRNOT00000078175.3
    7. XM_063285666.1XP_063141736.1  dynactin subunit 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ASG8
    8. XM_063285668.1XP_063141738.1  dynactin subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A3U0
    9. XM_039107182.2XP_038963110.1  dynactin subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ASG8
      Conserved Domains (5) summary
      TIGR02168
      Location:213533
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:9171030
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05109
      Location:101207
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:520798
      Dynactin; Dynein associated protein
    10. XM_063285665.1XP_063141735.1  dynactin subunit 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ASG8
    11. XM_063285667.1XP_063141737.1  dynactin subunit 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A3U0, D4A8U7, G3V7A8
      Related
      ENSRNOP00000059076.3, ENSRNOT00000068102.5